In this initial segment, epileptologist Jacqueline French, MD, discusses the often-overlooked burdens of epilepsy, including the anxiety of unpredictable seizures, mortality risk, and the demands of maintaining consistent treatment. For people with epilepsy, disease burden cannot be fully captured by counting seizures. The possibility that a seizure could occur without warning can affect how patients approach work, relationships, independence, and everyday activities, creating a persistent psychological burden even during periods when seizures are relatively infrequent.