Expert Perspectives on Recent Advances in Alzheimer’s Disease

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A panel of experts in dementia discusses the latest progress in the treatment of Alzheimer disease, and the various therapies that have progressed through the pipeline.

Current Understanding of Alzheimer’s Disease Pathology

EP. 1: Current Understanding of Alzheimer’s Disease Pathology

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
December 22nd 2022
Video

Four Alzheimer’s disease expert discuss our current understanding of Alzheimer’s disease pathology and the presence of amyloid and tau pathologies in patients.

Biomarkers and Challenges to the Use of Biomarkers in Alzheimer’s Disease

EP. 2: Biomarkers and Challenges to the Use of Biomarkers in Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
December 22nd 2022
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Drs Atri and Cohen discuss biomarkers for Alzheimer’s disease and the challenges in their use in routine practice.

Genetic and Structural Heterogeneity in Alzheimer’s Disease

EP. 3: Genetic and Structural Heterogeneity in Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
December 29th 2022
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Drs McDade and Sabbagh discuss heterogeneity in Alzheimer’s disease and structural polymorphism and genetic mosaicism seen in patients.

Ongoing Research and Use of Biomarkers and Imaging in Alzheimer’s Disease

EP. 4: Ongoing Research and Use of Biomarkers and Imaging in Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
December 29th 2022
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Dr Atri shares his excitement about ongoing research and the use of biomarkers and imaging for management Alzheimer’s disease.

Diagnostic Pathway for Alzheimer’s Disease

EP. 5: Diagnostic Pathway for Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
January 5th 2023
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Dr. Atri discusses his approach to diagnosis and Dr. McDade updates on the use of tau-PET for diagnosis of Alzheimer’s disease.

Importance of Primary Care Physicians in Diagnosis of Alzheimer’s Disease

EP. 6: Importance of Primary Care Physicians in Diagnosis of Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
January 5th 2023
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Dr Cohen emphasizes the importance of engagement of primary care physicians in identification of Alzheimer’s disease symptoms and pathology.

Use of ATN Classification for Alzheimer’s Disease in Clinical Practices

EP. 7: Use of ATN Classification for Alzheimer’s Disease in Clinical Practices

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
January 12th 2023
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Drs McDade and Cohen discuss ATN (amyloid, tau, neurodegeneration) classification and its use in clinical practice to manage Alzheimer’s disease.

Factors Contributing to Clinical Trial Failures in Alzheimer’s Disease

EP. 8: Factors Contributing to Clinical Trial Failures in Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
January 12th 2023
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Dr. Cohen shares factors that may have contributed to the high failure rate of Alzheimer’s disease clinical trials thus far.

Considerations for Management of Alzheimer’s Disease

EP. 9: Considerations for Management of Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
January 19th 2023
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Dr Atri discusses considerations and suggestions for caring for patients with Alzheimer’s disease.

Current Treatment Options for Alzheimer’s Disease

EP. 10: Current Treatment Options for Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
January 19th 2023
Video

Dr Cohen shares current treatment options for Alzheimer’s disease and how she manages these patients in her practice.

Management of Neuropsychiatric symptoms of Alzheimer’s Disease

EP. 11: Management of Neuropsychiatric symptoms of Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
January 26th 2023
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Dr Atri emphasizes importance of managing neuropsychiatric symptoms in patients with Alzheimer’s disease and drugs under development.

Treatment Pipeline for Alzheimer’s Disease

EP. 12: Treatment Pipeline for Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
January 26th 2023
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Drs McDade, Atri, Cohen, and Sabbagh discuss candidates drugs and various mechanisms of actions that are currently under evaluation for Alzheimer’s disease.

Aducanumab for Treatment of Alzheimer’s Disease

EP. 13: Aducanumab for Treatment of Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
February 2nd 2023
Video

Dr Atri discusses aducanumab, first FDA approved anti-amyloid-beta antibody for treatment of Alzheimer’s disease.

Management of Amyloid Related Imaging Abnormalities (ARIA) for Alzheimer’s Disease

EP. 14: Management of Amyloid Related Imaging Abnormalities (ARIA) for Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
February 2nd 2023
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Dr Atri comments on observation of amyloid related imaging abnormalities (ARIA) seen with many Alzheimer’s disease treatments and shares his thoughts on management of ARIA.

Lecanemab for Treatment of Alzheimer’s Disease

EP. 15: Lecanemab for Treatment of Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
February 9th 2023
Video

Drs Cohen, Atri, and Sabbagh share data on lecanemab, an anti-amyloid beta antibody, that was presented at CTAD 2022.

Other Anti-Amyloid Antibody Agents for Treatment of Alzheimer’s Disease

EP. 16: Other Anti-Amyloid Antibody Agents for Treatment of Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
February 9th 2023
Video

Drs McDade and Atri discuss differences and similarities between other ongoing anti-amyloid antibody trials in Alzheimer’s disease.

Data from Other Emerging Alzheimer’s Disease Treatment Options from CTAD 2022

EP. 17: Data from Other Emerging Alzheimer’s Disease Treatment Options from CTAD 2022

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
February 16th 2023
Video

Expert neurologists share information on drugs with different mechanisms of actions that are being evaluated in clinical trials for Alzheimer’s disease.

Prevention Trials in Alzheimer’s Disease

EP. 18: Prevention Trials in Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
February 16th 2023
Video

Dr Eric McDade shares information on different types of prevention trials to manage Alzheimer’s disease.

Future Outlook for Alzheimer’s Disease

EP. 19: Future Outlook for Alzheimer’s Disease

Marwan Sabbagh, MD;Alireza Atri, MD, PhD;Sharon Cohen, MD, FRCPC;Eric McDade, DO
February 16th 2023
Video

Drs Atri, Cohen, Sabbagh and McDade share their enthusiasm and optimism about the future outlook for Alzheimer’s disease.

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