Daridorexant and Next-Day Function: What Patients Are Reporting

EP: 1.Managing Insomnia: History, Comorbidities, and Clinical Insight

EP: 2.Building Consistency in Long-Term Management of Insomnia

EP: 3.Overview of DORA Class Medications for the Treatment of Insomnia

EP: 4.Counseling About Insomnia Medications Q6

EP: 5.From Trials to Treatment: Understanding the Treatment Profile of Daridorexant

EP: 6.Why Choose a DORA? Clinical Considerations for Patients With Insomnia

EP: 7.Clinical Perspectives on DORAs for Insomnia Management

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EP: 8.Daridorexant and Next-Day Function: What Patients Are Reporting

EP: 9.Looking at the Future of Insomnia Management

The best candidates for daridorexant, a dual orexin receptor antagonist, are individuals who suffer from chronic insomnia and require nightly sleep aids due to their persistent sleep issues. When considering this treatment, the age of the patient and any underlying comorbidities play a significant role in the decision-making process. Chronic insomnia patients who need long-term sleep support, with a focus on safety and tolerability, are ideal candidates for this medication.

However, daridorexant is not suitable for all patients. Specifically, those with narcolepsy should not be prescribed this medication, as it blocks orexin receptors, and orexin is already deficient in individuals with narcolepsy. This could exacerbate symptoms, including excessive sleepiness or even cataplexy, a condition involving loss of muscle tone triggered by strong emotions. Additionally, caution is needed when prescribing daridorexant to patients with chronic kidney or liver disease due to potential complications.

For patients with chronic insomnia, especially those complaining of daytime sleepiness, daridorexant is considered a preferable option. The medication provides an effective solution to help manage sleep and minimize adverse effects such as daytime sleepiness. If patients have concerns related to parasomnia or memory issues, daridorexant remains a strong candidate compared to other sleep aids. Working with patients to address their sleep challenges while providing a safer and well-tolerated treatment is crucial for effective management of chronic insomnia.