Episode 171: Fragile X Syndrome Day: Clinical Challenges, Care Strategies, and Emerging Therapies

Episode 171 of the NeurologyLive^® Mind Moments^® podcast is now live! Scroll down to listen or click here to subscribe on your favorite streaming service.

The Mind Moments podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis (MS), Parkinson disease, dementia, sleep disorders, and more.

In episode 171, “Fragile X Syndrome Day: Clinical Challenges, Care Strategies, and Emerging Therapies” Craig A. Erickson, MD, professor of psychiatry at Cincinnati Children’s Hospital, discussed the evolving landscape of Fragile X syndrome (FXS) care in honor of National Fragile X Syndrome Day. Erickson reviewed current challenges in recognizing and diagnosing FXS. He also underscored the importance of genetic testing and outlined key counseling points for families once a diagnosis is confirmed.

Erickson, who also serves as the director of the Cincinnati Fragile X Research and Treatment Center, provided an overview of behavioral and neuropsychiatric management across the lifespan. He highlighted evidence-informed approaches for ADHD, irritability and aggression, and anxiety, as well as the critical role of early intervention and structured supports in adulthood. The discussion closed with a look at emerging therapeutics, and how these advances may reshape clinical practice and long-term outcomes for individuals with FXS.

The stories featured in this week’s Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

• FDA Accepts BLA for Z-Rostudirsen in DMD, Sets January PDUFA Date
• FDA Accepts NDA for Apnimed’s AD109 for the Treatment of Obstructive Sleep Apnea
• FDA Accepts NDA for Axsome Therapeutics’ AXS-12 for the Treatment of Cataplexy in Narcolepsy

EPISODE BREAKDOWN

• 1:25 – Challenges in recognizing and diagnosing Fragile X 
• 3:25 – Genetic counseling and cascade testing after diagnosis 
• 6:00 – Managing behavioral and neuropsychiatric symptoms 
• 9:55 – News Minute 
• 12:45 – Clinical management across the lifespan 
• 17:12 – Emerging therapies and research priorities 
• 21:17 – Why Fragile X awareness remains critical 

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