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Opinion|Videos|October 11, 2024

Meningococcal Infection and NMOSD

Author(s)Sean Pittock, MD

Key Takeaways

Eculizumab and ravulizumab increase meningococcal infection risk, necessitating vaccination in treated patients.
Phase 3 and long-term studies emphasize the need for vigilant monitoring and prophylactic measures despite vaccination.
Breakthrough infections can occur even with vaccination, highlighting the need for ongoing risk assessment.
The impact of meningococcal vaccination on disease relapse activity requires further investigation.

SHOW MORE

Sean Pittock, MD, discusses the risks of meningococcal infection associated with eculizumab and ravulizumab in phase 3 and long-term extension studies, as well as his interpretation of the concerns surrounding meningococcal vaccination and its potential impact on relapse activity.

Episodes in this series

EP. 1 Relapses and Disability Accumulation in NMOSD

EP. 1 Relapses and Disability Accumulation in NMOSD

EP. 2 Treatments With Higher Efficacy and Relapses in NMOSD

EP. 2 Treatments With Higher Efficacy and Relapses in NMOSD

EP. 3 Ravulizumab Long-Term Data and Management of NMOSD

EP. 3 Ravulizumab Long-Term Data and Management of NMOSD

EP. 4 The Evolving Understanding of NMOSD Pathophysiology and the Role of Complement System

EP. 4 The Evolving Understanding of NMOSD Pathophysiology and the Role of Complement System

EP. 5 Treatment Options to Manage and Prevent Relapses in NMOSD

EP. 5 Treatment Options to Manage and Prevent Relapses in NMOSD

EP. 6 Importance of Diverse Mechanisms of Action to Effectively Treat NMOSD

EP. 6 Importance of Diverse Mechanisms of Action to Effectively Treat NMOSD

EP. 7 Complement Inhibitors in NMOSD

EP. 7 Complement Inhibitors in NMOSD

EP. 8 Meningococcal Infection and NMOSD

EP. 8 Meningococcal Infection and NMOSD

EP. 9 Long-term NMOSD Data

EP. 9 Long-term NMOSD Data

EP. 10 Use of Long-term NMOSD Data in Clinical Practice

EP. 10 Use of Long-term NMOSD Data in Clinical Practice

Video content above is prompted by the following:

Discuss the risk of meningococcal infection with eculizumab and ravulizumab in phase 3 and long-term extension studies.
There may be concerns with meningococcal vaccination and its impact on relapse activity. What is your interpretation of these data?

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