Neurofilament Light Chain and MS Prognosis, Treatment Effect, and Anticipation of Disease

In this segment, Ahmed Obeidat, MD, PhD, provides a concise summary of recent studies that investigated the correlation between neurofilament light chain (NFL) levels and long-term disability in multiple sclerosis (MS) patients. He mentions that these studies indicate a potential role for NFL in predicting disability accumulation over several years, challenging the previous assumption that NFL primarily correlates with inflammation rather than the neurodegenerative process.

Ahmed Obeidat, MD, PhD, also highlights that the predictive power of NFL seems more robust in the relapsing MS population compared to those with progressive MS. He emphasizes the accumulating evidence from various cohorts and countries supporting the potential use of NFL, along with other biomarkers, in predicting long-term outcomes on a population level.