NeurologyLive® Friday 5 — December 19, 2025

Welcome to NeurologyLive^®'s Friday 5! Every week, the staff compiles 5 highlights of NeurologyLive's widespread coverage in neurology, ranging from newsworthy study findings and FDA action to expert interviews and peer-to-peer panel discussions.

Click the read more and watch now buttons for more details and information about each highlight.

1: 2024 Primary Stroke Prevention Guidelines: Key Takeaways and Clinical Implications

In a recent Q&A, Walter Kernan, MD, senior research scientist at Yale University, discussed the latest primary stroke prevention guidelines and their focus on lifelong brain health and risk factor management.

2: Clinical Insights on the Long-Term Efficacy, Safety Profile of Bexicaserin in Developmental Epileptic Encephalopathies: Johannes Streffer, MD

In a recent interview, Johannes Streffer, MD, the senior vice president of clinical development for Lundbeck, provided in-depth commentary on the mechanism of bexicaserin, and the promising early-stage data shown in those with developmental epileptic encephalopathies. [WATCH TIME: 4 minutes]

3: Understanding the Therapeutic Potential and Promising Early-Stage Data on Azetukalner for Focal Onset Seizures

In a recent Q&A, Christopher Kenney, MD, FAAN, chief medical officer at Xenon Pharmaceuticals, reviews encouraging long-term data behind azetukalner, a first-in-class Kv7 channel opener, as a potential treatment for focal onset seizures.

4: Improving Outcomes for Older Adults With Epilepsy: Anny Reyes, MD

In a recent interview at AES 2025, Anny Reyes, MD, a clinical neuropsychologist at the Cleveland Clinic Epilepsy Center, discussed the growing challenges facing older adults with epilepsy and the need for more comprehensive, research-informed care strategies. [WATCH TIME: 4 minutes]

5: Refining Prognosis and Treatment in Post–Resuscitation Epilepsy Care

In a recent Q&A, Andrea Rossetti, MD, director of the EEG/Epilepsy Unit at the Department of Clinical Neurosciences the Lausanne University Hospital in Switzerland, offers insight into post-resuscitation epilepsy care.