NeurologyLive® Friday 5 — December 26, 2025

Welcome to NeurologyLive^®'s Friday 5! Every week, the staff compiles 5 highlights of NeurologyLive's widespread coverage in neurology, ranging from newsworthy study findings and FDA action to expert interviews and peer-to-peer panel discussions.

Click the read more buttons for more details and information about each highlight.

1: What’s All the Buzz? Trending Topics and Phrases of Neurology in 2025

In 2025, several buzzwords gained traction as neurologists navigated increasingly data rich and biologically complex care. Terms such as artificial intelligence, gene therapy, personalized therapy, neuroplasticity, and genetics became central to conversations across subspecialties, reflecting a growing emphasis on precision medicine, disease modification, and individualized approaches to neurologic care.

2: NeurologyLive® Year in Review 2025: Top Interviews in Multiple Sclerosis Care

Over the past 12 months, there have been several significant advances in the field of multiple sclerosis (MS), including including a growing emphasis on earlier identification of disease progression independent of relapse activity; refined diagnostic frameworks for pediatric, late-onset, and atypical presentations; and a continued shift toward early, high-efficacy treatment strategies.

3: Real-World Use of Clinical Biomarkers in the Updated Multiple Sclerosis Diagnostic Criteria

As part of This Year in Medicine, an annual series reviewing the most impactful developments in health care, NeurologyLive invited multiple sclerosis experts to discuss the clinical application of the updated criteria, including the use of the central vein sign, paramagnetic rim lesions, and kappa free-light chain concentrations in cerebrospinal fluid.

4: NeuroVoices: Joseph Sullivan, MD, on ETX101 Gene Regulation Therapy and Early POLARIS Findings in Dravet Syndrome

During the 2025 AES Annual Meeting, NeurologyLive sat down with Joseph Sullivan, MD, director of the Pediatric Epilepsy Center at UCSF, to discuss some of the findings presented, along with the mechanism and rationale behind this new therapeutic. As part of a new NeuroVoices, Sullivan walked through the global POLARIS program, as well as previewed some of the promising findings on seizure burden and neurodevelopmental measures further supporting EXT-101’s development.

5: NeurologyLive® Year in Review 2025: Top Podcast Episodes

Throughout the course of the year, the NeurologyLive team put together nearly 30 episodes of our podcast, Mind Moments^®, which features quick, digestible interviews with experts on trending topics in clinical neurologic care. The podcast, which releases new episodes every other Friday (in addition to special episodes, on occasion), is available to listen across most major podcast platforms.