Recognition and Paradigm Shift in Treatment Strategies for OFF Fluctuations and Dyskinesia in Parkinson’s Disease


The neurology doctors discuss motor fluctuations and dyskinesia associated with Parkinson’s Disease.

To watch the video series component of this episode, click here.

0:00 Introduction

1:04 Off Fluctuations and Dyskinesia are still an Unmet Need in Parkinson’s Disease (PD)

3:44 Setting Patient Expectations and Recognizing OFF Fluctuations

7:58 Changes in Understanding of OFF in PD

9:46 Importance of Gut Physiology in PD

12:33 Treating both OFF Fluctuations and Dyskinesia in Patients with PD

13:43 Formulations of Levodopa

15:21 Dopamine Agonists in PD

17:53 Non-dopaminergic Strategies

18:40 Amantadine DR/ER in PD

20:21 Shifting the Paradigm towards Management of Motor Complications in PD

23:11 On-demand Therapy and Optimization of “Time to ON”

28:44 Istradefylline

29:32 Emerging Treatments and Pearls to Physicians, Patients and Caregivers

35:07 Final Remarks

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