Recognition and Paradigm Shift in Treatment Strategies For OFF Fluctuations and Dyskinesia in Parkinson’s Disease
The neurology doctors discuss motor fluctuations and dyskinesia associated with Parkinson’s Disease.
0:00 Introduction
1:04 Off Fluctuations and Dyskinesia are still an Unmet Need in Parkinson’s Disease (PD)
3:44 Setting Patient Expectations and Recognizing OFF Fluctuations
7:58 Changes in Understanding of OFF in PD
9:46 Importance of Gut Physiology in PD
12:33 Treating both OFF Fluctuations and Dyskinesia in Patients with PD
13:43 Formulations of Levodopa
15:21 Dopamine Agonists in PD
17:53 Non-dopaminergic Strategies
18:40 Amantadine DR/ER in PD
20:21 Shifting the Paradigm towards Management of Motor Complications in PD
23:11 On-demand Therapy and Optimization of “Time to ON”
28:44 Istradefylline
29:32 Emerging Treatments and Pearls to Physicians, Patients and Caregivers
35:07 Final Remarks
