Abby Reinhard, Assistant Editor for NeurologyLive, has covered medical news for MJH Life Sciences, NeurologyLive’s parent company, since 2021. Email her at email@example.com
Onset Presentation Predicts First Relapse, Long-Term Disability in Pediatric AQP4-IgG NMOSD
Investigators suggest recognition of predictors can aid in directing future clinical trials, as well as inform early therapeutic decisions in this patient population.
XEN1101 Meets Phase 2b Primary, Secondary End Points in Focal Epilepsy
Monthly focal seizure frequency was reduced from baseline at all 3 dose levels of the differentiated Kv7 potassium channel modulator, compared to placebo.
Epilepsy Associated With Disability Progression in Multiple Sclerosis
Data from 31,052 patients on the German Multiple Sclerosis Register were analyzed in the case-control study.
Ublituximab Biologics License Application Submitted for Relapsing MS
Application follows the results of 2 independent, identical phase 3 trials, ULTIMATE 1 and 2, which assessed the TG Therapeutics anti-CD20 antibody in more than 1000 patients.
Data Illustrate Efficacy of Risdiplam in SMA and SRP-9001 in DMD
Findings from studies of the neuromuscular treatments were presented by at the 2021 World Muscle Society Virtual Congress, September 20-24.
Cala Trio TAPS Device Reduces Severe Tremor in Patients With ET
When used for at least 30 days, it was reported that patients with essential tremor reported improvement in tremor power following 54% of sessions.
Evaluating the Association of Anesthesia, Surgery, and Cognitive Decline in Older Adults
Susana Vacas, MD, PhD, discussed a recent article that outlined postoperative neurocognitive disorders and the association with anesthesia in older adults undergoing surgery.
Survey Identifies New Phenotypic Features for Patients With NMOSD in Latin America
The study is the first to provide data from all Latin American countries, further identifying geographic-resultant limitations of access to technology and therapy for NMOSD.
Integrating Occupational Therapy into Neuromuscular and Movement Disorders Care
Jess Holguin, OTD, OT/L, spoke on the unique role occupational therapists can play for patients with neuromuscular and movement disorders.
Ataluren Delays Loss of Ambulation by 5 Years in Nonsense Mutation DMD
Data from the STRIDE patient registry showed that treatment was also associated with a delay in pulmonary function decline for those with Duchenne muscular dystrophy.
MDS Congress 2021: Highlights, Takeaways, and Future Research
Following MDS 2021, we compiled a roundup of some of our discussions with experts in the Parkinson disease and movement disorders space in one convenient location.
The Impact of Telehealth on Patient Experiences in Sleep Medicine
Lucas M. Donovan, MD, MS, discussed key takeaways from a recent study evaluating the integration of telehealth during the COVID-19 pandemic.
Sex Differences Identified With Caregiver Burden in Parkinson Disease
Data suggest that certain activities of daily living are more prevalent depending on whether the caregiver is a man or a woman.
Discussing the Efficacy of SAGE-324 in Treating Essential Tremor
Helen Colquhoun, MD, vice president of early development at Sage Therapeutics, commented on results from a phase 2 study in which patients receiving SAGE-324 showed a significant decrease in ET.
Survey Finds Barriers to Access, Availability of Genetic Testing for Parkinson Disease
Data were collected from the MDS’s membership worldwide, assessing current practices, concerns, and barriers to genetic testing.
Dance Class Intervention Safe for Patients With Parkinson Disease
Data found that synchronic dance classes conducted through Zoom may be particularly effective for patients who live remotely.
Treatment With SAGE-324/BIIB124 Reduces Upper Limb Tremor Score
Patients were evaluated at day 29 for change in TETRAS item 4 score change from baseline.
Higher Recurrence Risk, Triptan Use Linked to Perimenstrual Migraine Duration
Women with perimenstrual migraine attacks may also be at increased risk of medication overuse.
Medical Cannabis Improves Related Pain, Symptoms of Dystonia
Investigators noted the psychiatric adverse effects of treatment with medical cannabis, requiring patient monitoring after initiation.
COVID-19 Stressors Associated With Poorer Mental Health in Parkinson Disease
Data from the PRIME-NL study showed stressors resulting from the pandemic impacted depression, anxiety, and quality of life.
Home-Based, Computerized Working Memory Programs Viable for Neurofibromatosis Type 1
Participants in the pilot study saw improvements in short-term memory, attention, and executive functioning.
Phase 3b Study of Higher-Dose Nusinersen in Patients With SMA Announced
Initiated by Biogen, the study will evaluate the effectiveness of the treatment in patients previously treated with risdiplam (Evrysdi; PTC Therapeutics).
COVID-19 Pandemic Associated With Sleep Disturbances in Children, Adolescents
Investigators found that preschool children had fewer sleep disturbances than older children during home confinement.
Investigational Encephalopathy Agent LP352 Safe and Effective in Phase 1 Trial
Longboard Pharmaceuticals plans to initiate a phase 1b/2a trial to determine the efficacy of the 5-HT2c receptor superagonist in patients with developmental and epileptic encephalopathies.
The Potential Need for a COVID-19 Vaccine Booster in Multiple Sclerosis
Joshua Katz, MD, commented on the possibility of an extra vaccine dose for patients with MS and experts’ hope to improve antibody response among the immunocompromised.
Takeaways From the Second Annual Student Sleep Health Week
Raman Malhotra, MD, president of the American Academy of Sleep Medicine, discussed the initiative, which emphasizes the importance of healthy sleep for students.
The Role of Organizations and Individuals in Addressing the Neurologist Shortage
Jennifer Majersik, MD, MS, commented on how the AAN, as well as current neurologists and specialists, can help generate interest in the field of neurology to meet patient needs.
BotulinumtoxinA Improves Spasticity in Adults With Cerebral Palsy
Additional functional outcomes and gait analysis showed mixed results when using botulinumtoxinA in those with CP.
Addressing the Neurologist Shortage and Increased Need for Neurologic Care
Jennifer Majersik, MD, MS, division chief of vascular neurology at the University of Utah, discussed contributing factors to the neurologist shortage, as well as ongoing efforts to increase interest in the field.
Lower Blood Pressure Linked to CPAP Adherence in Those With OSA and Type 2 Diabetes
Investigators identified a potential dose-response relationship between lower systolic blood pressure and rate CPAP-adherence rates in those with both OSA and type 2 diabetes.
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