Abby Reinhard, Assistant Editor for NeurologyLive, has covered medical news for MJH Life Sciences, NeurologyLive’s parent company, since 2021. Email her at email@example.com
NeurologyLive® Brain Games: March 20, 2022
Test your neurology knowledge with NeurologyLive®'s weekly quiz series, featuring questions on a variety of clinical and historical neurology topics. This week's topic is optic neuritis and neuromyelitis optica spectrum disorder (NMOSD).
Infant Sleep at 4 Months Indicative of 18-Month Neurodevelopmental Outcomes
Future research is required to include EEG analyses of neurodiverse patient populations.
New MOXIe Extension Trial Results Consistent With Persistent Effect of Omaveloxolone in Friedreich Ataxia
Updates from the open-label, delayed-start period of the pivotal 2-part MOXIe trial (NCT02255435) support previous positive primary end points findings from part 2 of the study.
CBT-I Linked to Poorer Neurocognitive Performance in Comorbid Insomnia and Sleep Apnea
Investigators compared the effect of cognitive behavior therapy for insomnia alone, continuous positive airway pressure alone, and combined treatment.
Wearable Sensors Feasible, Reliable for Measuring Functional Performance in FSHD
Data may be useful when analyzing disease progression and treatment efficacy in future facioscapulohumeral muscular dystrophy clinical trials.
Casimersen Increases Exon Skipping, Dystrophin Expression in Patients With DMD Amenable to Exon 45 Skipping
The treatment was well tolerated at 48 weeks in patients with DMD with a confirmed mutation amenable to exon 45 skipping.
Outlining Areas of Unmet Need and Next Steps for Research in MS
Speaking on his own presentation on economic burden in MS, Bruce Bebo, PhD, further shared his thoughts on areas of unmet need and the potential relationship of Epstein-Barr virus and MS.
NeurologyLive® Brain Games: March 13, 2022
Test your neurology knowledge with NeurologyLive®'s weekly quiz series, featuring questions on a variety of clinical and historical neurology topics. This week's topic is sleep disorders.
Serum GFA Identified as a Biomarker for NMOSD, sNfL as a Predictor of Poor Post-Attack Outcomes
A systematic literature review of randomized controlled trials in neuromyelitis optica spectrum disorder was performed, with 7 studies identified and 2 used in analyses.
Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis Is Safe, Efficacious Over Long-Term
Investigators noted the long-term cost-effectiveness and safety of this approach, as it does not require the regular use of disease-modifying therapies.
Higher-Dose Antiseizure Medications, Early Therapeutic Monitoring Necessary for Pregnant Women With Epilepsy
The study had a goal to provide a personalized treatment approach, including ASM dosage changes to prevent seizure worsening and optimizing the balance of outcomes for mothers and children.
IND Application Accepted for Phase 2b Trial of NOE-101 in Trigeminal Neuralgia
Data from the 24-week, multicenter LibraTN trial are expected to be reported in the first half of 2024.
Addressing ‘Staggering’ Economic Burden for Patients With Multiple Sclerosis
Bruce Bebo, PhD, outlined findings from a recent analysis presented at ACTRIMS Forum 2022, with investigators concluding costs associated with the disease have previously been underestimated.
Geographic Gaps, Therapist Availability Significantly Associated With Poststroke Rehabilitation Care Utilization
The cohort study was conducted in Taiwan, with investigators also observing changes over time in the influence of sex, stroke type, and copayment exemption type of rehabilitation utilization.
No Greater Risk of Serious COVID-19, Severe Outcomes Linked to Cladribine Treatment
Data provide an update to the post-approval safety profile of cladribine tablets in patients with relapsing MS in reference to COVID-19 infections.
COVID-19 Pandemic Associated With Higher Mortality in Elderly With Alzheimer Disease and Related Dementias
Investigators also found that this association was particularly pronounced among those living in nursing homes, as well as in Asian, Black, and Hispanic populations.
Discussing the Need for Genetic Testing and Counseling in Parkinson Disease
With the Parkinson’s Foundation recently being granted Joint Accreditation and announcing a new and free CME course, James Beck, PhD, senior vice president and chief scientific officer of the organization, commented on the pivotal role genetic testing can play.
MS Relapses, Health Care Utilization Greatest Among COVID-19 Vaccinated Patients Treated With Ocrelizumab, Fingolimod
Previously reported data show patients with multiple sclerosis treated with anti-CD20s have reduced response to COVID-19 vaccines, but there has been limited research on MS outcomes among vaccinated patients.
NeurologyLive® Brain Games: March 6, 2022
Test your neurology knowledge with NeurologyLive®'s weekly quiz series, featuring questions on a variety of clinical and historical neurology topics. This week's topic is nutrition in multiple sclerosis.
Risk of Persistent, Early Symptoms of Poststroke Depression Increased With Severity of Neurological, Functional Deficits
Data were analyzed from the AFFINITY study cohort, which included men and women recruited within 2 weeks of stroke onset in Australia, New Zealand, and Vietnam.
Ketogenic Diet Reduces Depression, Improves Quality of Life in Multiple Sclerosis
Results from the preliminary study investigating the safety of the ketogenic diet for patients with MS were announced ahead of the AAN Annual Meeting in April 2022.
Fosgonimeton Safe, Well Tolerated in Patients With Alzheimer Disease
The treatment is being developed as a first-in-class regenerative therapy for those with AD and dementia, with these safety data offering support to its development.
1-Year Disability Progression, Improvement Similar for Patients With Primary, Secondary Progressive MS
Investigators noted the need for more transformational treatments to improve disability for patients with both primary and secondary progressive multiple sclerosis.
Online Adaptive Cognitive Training, tDCS Feasible for Patients With Multiple Sclerosis
Data suggest that there is a greater cognitive benefit for patients with higher levels of baseline neurological disability treated with the training and transcranial direct current stimulation.
MS Treatment With Tolebrutinib Uninterrupted in Patients With COVID-19 Infection
The study found that all COVID-19 cases were mild to moderate in severity, and all enrolled patients recovered and remained in the study.
Silent Clinical Progression Predominantly Associated With Cervical Cord Atrophy
Investigators utilized a novel method to accurately capture spinal cord area at C1 vertebral level from legacy brain MRI scans.
Rare Disease Day: Updates on Rare Neurological Diseases
In recognition of Rare Disease Day, the NeurologyLive® team offered an extensive update on the state of care and treatment for a wide range of rare neurological diseases, including Kleine-Levin syndrome, amyotrophic lateral sclerosis, cerebral palsy, Lennox-Gastaut syndrome, and more.
Cortical Lesion Burden Associated With Disability Worsening, Transition to Progressive Multiple Sclerosis
Three-year follow-up data presented at the ACTRIMS Forum 2022 suggest cortical lesion burden, particularly subpial lesions, is the primary driver of worsening disability and conversion to secondary progressive MS.
Cycling Intervention Shows Modest Improvement in Walking Measures for Secondary Progressive Multiple Sclerosis
Additional study is required to further investigate the integration of FES cycling into clinical practice for management of SPMS.
MSDA Test Identified as Biomarker-Based Instrument to Assess Disease Activity in Multiple Sclerosis
Investigators concluded that the Multiple Sclerosis Disease Activity test can assist in monitoring therapeutic response to glatiramer acetate and biologic agents.
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