Authors
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Sigma-1 Agonists Offer Combination Approach to Dementia SymptomsResearch from the past decade suggests that sigma-1 receptors and their encoding gene, SIGMAR1, together act as a therapeutic target for patients with dementia.
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Ian Miller, MD: Adapting AAV Gene Therapy for SCN1A-Positive EpilepsyThe medical director of the Comprehensive Epilepsy Clinic at Nicklaus Children’s Hospital discusses his early stage gene therapy trial for Dravet syndrome.
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Early High-Efficacy TreatmentJames Stankiewicz, MD, provides an overview of the burden of multiple sclerosis and discusses early, high-efficacy treatment of the disease.
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Peter Calabresi, MD: Utilizing A Uniform Biomarker AssayFor the director of the Johns Hopkins Multiple Sclerosis Center, a biomarker is perhaps only as useful as the clinician community’s ability to read out its measurements.
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Robert S. Fisher, MD, PhD: Exploring Unanswered Questions in EpilepsyThe Director of the Stanford Epilepsy Center discussed the work that’s left to be done in the field of epilepsy.
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Geoff Kerchner, MD, PhD: Phase III Trials of Crenezumab in Treatment of Prodromal to Mild AlzheimerData back a 4-fold higher dose of crenezumab in the CREAD 1 and CREAD 2 trials than used in phase II.
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Targeting the NF-kB Pathway in Duchenne Muscular DystrophyAn in-depth analysis of the genetics of DMD and disease modifiers such as the NF-kB pathway in patients with Duchenne muscular dystrophy.
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Daniel M. Goldenholz, MD, PhD: Assessing the Risk for SUDEPThe instructor in neurology at Beth Israel Deaconess Medical Center spoke about what clinicians can do right now to mitigate the risk of SUDEP and the myriad of options for them to utilize.
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World Alzheimer Day 2019: Key Takeaways From Leaders in Alzheimer Disease and DementiaIn recognition of World Alzheimer Day, experts in Alzheimer disease and dementia share insight from the latest Alzheimer Disease International's yearly World Alzheimer Report.
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Understanding Clinical Predictors of Response to Nabilone in Alzheimer AgitationKrista L. Lanctôt, PhD, professor of psychiatry and pharmacology at the University of Toronto, talked about findings from a recent post hoc analysis presented at CTAD 2024 on nabilone for agitation in Alzheimer disease.
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Dina Katabi, PhD: Biosensors for Measuring Disease Activity in MS and Other Neurological DisordersThe Andrew & Erna Viterbi Professor of Electrical Engineering and Computer Science at MIT spoke about a new way of continuous monitoring for patients with MS and neurodegenerative disorders, discovering changes in quality of life and new biomarkers.
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Screening for Alzheimer Disease: Facilitating an Early Diagnosis for Prompt InterventionIn this episode of MEDcast, expert geriatric psychiatrists explore the urgent need for effective diagnostic methods that can detect Alzheimer’s disease at an early stage. We will discuss blood-based biomarkers and other advancements that can help screen Alzheimer’s disease non-invasively and early in the disease course.
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Safety and Efficacy Considerations of Newly Approved Combination Therapy for Acute Migraine: Richard B. Lipton, MDThe director of the Montefiore Headache Center at Albert Einstein College of Medicine provided an overview of the drug profile for the recently approved migraine treatment AXS-07. [WATCH TIME: 3 minutes]
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The Female Leaders Who Shaped an Epilepsy Icon: Reflections From Jacqueline A. French, MDJacqueline A. French, MD, a professor of neurology at the NYU Grossman School of Medicine, provided clinical perspectives on her experiences and career growth in neurology amid National Women Physicians Day.
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Revised McDonald Diagnostic Criteria Signals New Era in Multiple Sclerosis TreatmentThe 2024 revisions to the McDonald diagnostic criteria for multiple sclerosis (MS) mark a significant advancement in the early detection and diagnosis of the disease, with new biomarkers and a broadened scope that may lead to earlier intervention and improved patient outcomes.
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Antje Bischof, MD: Understanding Vasculitic NeuropathyThe postdoctoral scholar at the University of California San Francisco discussed the findings from her study that gives comprehensive insight into prevalence and organ associations of vasculitic neuropathy.
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Final Advice for Clinicians Treating NarcolepsyDrs Thorpy, Dogan, Doghramji, and Kushida share clinical pearls for primary care providers who are taking care of patients with narcolepsy.
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Glenn Wylie, DPhil: The Future of Real-Time NeurofeedbackThe director of the Rocco Ortenzio Neuroimaging Center at Kessler Foundation spoke about the future of functional MRI in providing real-time neurofeedback, and how it might be incorporated as an end point in clinical trials.
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Erin Conrad, MD: Identifying the Seizure Onset ZoneThe epilepsy fellow at the hospital of the University of Pennsylvania detailed why locating the seizure onset zone plays a crucial role in successful epilepsy surgery.
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Fred Rincon, MD, MSc : Expanding Stroke Treatment Outside of NeurologyThe chief of cerebrovascular disease at Jefferson University Hospitals explains why teaching stroke protocol and using telemedicine can help close the gaps in stroke care.
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Targeting the Neonatal Fc Receptor in Myasthenia GravisUnderstanding the pathophysiology of myasthenia gravis is still being determined to this day, but the neonatal Fc receptor is emerging as a potential treatment.
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The Rationale Behind Recently Approved AXS-07 Combination Therapy for Migraine: Stewart Tepper, MDThe professor of neurology at the Geisel School of Medicine at Dartmouth talked about how the combination therapy involving meloxicam and rizatriptan may provide a more effective approach to treating migraine. [WATCH TIME: 6 minutes]
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Marie D'hooghe, MD, PhD: Pregnancy Plans for Patients With MSThe neurologist at the National MS Center and University Hospital, in Brussels, discussed the clinician mindset when treating women with MS who plan to get pregnant, and how patients using assistive reproductive treatments should be approached.
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Elizabeth Thiele, MD, PhD: CBD Shows Low-Dose Efficacy and Safety in TSCThe director of pediatric epilepsy and the Herscot Center for Tuberous Sclerosis Complex at Massachusetts General Hospital, and professor of neurology at Harvard Medical School spoke to the safety outcomes from GWPCARE6 and CBD’s low-dose efficacy.
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Advancing MS Research Through Recognition and Innovation: The John Dystel PrizeBruce Bebo, PhD, and Amit Bar-Or, MD, FRCPC, FAAN, FANA, discussed the impact of the John Dystel Prize on multiple sclerosis research and its role in shaping future clinical advancements.
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Brian J. Murray, MD: Establishing Normal Values in PolysomnographyThe head of neurology at the Sunnybrook Health Sciences Centre of the University of Toronto spoke about the limited available normative sleep data, and shared insight into the findings of the meta-analysis he and colleagues conducted of more than 150 studies.
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Progress for Patients With Pediatric MS, Fingolimod's Risk-Benefit Profile: Brenda Banwell, MDThe chief of neurology and codirector of the neuroscience Center at the Children's Hospital of Philadelphia spoke about her presentation at ECTRIMS 2022 on the treatment of pediatric MS. [WATCH TIME: 5 minutes]
