Advances in Orexin-Based Therapies: Key Updates From the Past 6 Months
From FDA regulatory milestones for investigational agents to emerging clinical data across sleep disorders, this roundup highlights notable developments shaping the evolving landscape of orexin-targeted therapies.
World Sleep Day is an annual global awareness campaign held on the Friday before the March equinox to promote the importance of healthy sleep and the prevention and management of sleep disorders. Organized by the World Sleep Society, the initiative was first launched in 2008 and brings together clinicians, researchers, and public health advocates to raise awareness of sleep health and the growing burden of sleep-related conditions worldwide. Each year features a dedicated theme, such as the 2026 theme, “Sleep Well, Live Better”, to emphasize the role of restorative sleep in supporting physical, cognitive, and emotional health.1