Careful planning and monitoring is important for women with epilepsy who become pregnant. Several studies from AES 2016 address pregnancy issues.
Studies presented at the 2016 American Epilepsy Society Scientific Sessions examined pregnancy issues in women with epilepsy. One study looked at predictors of unintended pregnancy, another discussed antiepileptic drug prescribing patterns, and two studies reported on specific drugs, brivaracetam and lamotrigine, taken during pregnancy.Â
Does the rate of unintended pregnancy in women with epilepsy vary by contraceptive category and/or antiepileptic drug (AED) category?
There is a high rate of unintended pregnancies in women with epilepsy, especially in those using oral hormone forms of contraception and taking enzyme-inducing AEDs
In animal studies, brivaracetam (BRV) showed evidence of developmental toxicity at plasma exposures greater than clinical exposures, but what was the clinical experience of pregnant women?
There seems to be no particular risk with BRV during pregnancy, but only a few pregnancies have been reported to date. Researchers advise BRV use in pregnancy only if benefit to mother outweighs risk to fetus.
Antiepileptic Drug Prescribing Patterns in Pregnant Women with Epilepsy: Findings from the MONEAD Study
Further MONEAD studies will include maternal outcomes and neurodevelopmental effects, as well AED prescriptions by seizure types, frequency, and other epilepsy factors.
Clearance Changes of Lamotrigine during Pregnancy Are Detectable within the First Trimester of Pregnancy