Commentary|Podcasts|September 18, 2026

Episode 175: Advancing the Ways of Treating Cluster Headache

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Jennifer Fokas, MD, and Minali Nigam, MD. [LISTEN TIME: 21 minutes]

Episode 171 of the NeurologyLive® Mind Moments® podcast is now live! Scroll down to listen or click here to subscribe on your favorite streaming service.

The Mind Moments podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis, Parkinson disease, dementia, sleep disorders, and more.

In episode 175, “Advancing the Ways of Treating Cluster Headache,” Jennifer Fokas, MD, and Minali Nigam, MD, neurologists at Northwestern Medicine with specialized training in headache medicine, join the podcast to discuss current challenges and evolving strategies in the management of cluster headache. They highlighted the substantial burden of disease, particularly among patients with chronic cluster headache, and the diagnostic difficulties that arise from overlap with migraine features. They emphasized the importance of recognizing cranial autonomic symptoms as key distinguishing features, along with typical attack duration and circadian or seasonal patterns.

The conversation also covered practical approaches to acute and preventive treatment, including high-flow oxygen via non-rebreather mask, subcutaneous sumatriptan, bridge therapies, and preventive options such as high-dose verapamil and, in selected cases, lithium. The physicians also review emerging and adjunctive options while noting limitations in evidence, indications, and access. They concluded by underscoring the need for clinician preparedness and tailored therapy to enable more assertive and appropriate management of cluster headache.

The stories featured in this week’s Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

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EPISODE BREAKDOWN

  • 1:54 – Biggest unmet need in cluster headache
  • 5:01 – Importance of multimodal acute management and access issues
  • 7:39 – Neurology News Minute 
  • 10:03 – Emerging and experimental therapies
  • 13:03– Preventive options and special situations
  • 17:51 – Key clinical takeaway: preparation and access to therapies

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REFERENCE
1. Burish MJ, Pearson SM, Shapiro RE, Zhang W, Schor LI. Cluster headache is one of the most intensely painful human conditions: Results from the International Cluster Headache Questionnaire. Headache. 2021;61(1):117-124. doi:10.1111/head.14021

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