Opinion|Videos|December 16, 2024

Exploring DMTs: Blood-Brain Barrier Penetration and Cognitive Health Benefits

Author(s)Gabriel Pardo, MD, FAAN
Martin Belkin, DO

Panelists discuss how disease-modifying therapies (DMTs) like dimethyl fumarate, fingolimod, and cladribine demonstrate potential blood-brain barrier penetration, offering neuroprotective mechanisms. While these therapies show promise in mitigating cognitive decline, their impacts vary, highlighting the complex interplay among neuroinflammation, immune modulation, and cognitive preservation in multiple sclerosis management.

Video content above is prompted by the following:

Which of the DMTs can penetrate the blood-brain barrier and have the potential to impact brain health directly?
What is our understanding of the impact of various DMTs on cognitive health?

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