Managing Disease Progression in MS: Changing Treatments and Clinician Advice

Key Takeaways

• Disease progression on high-efficacy therapy necessitates strategic treatment modification, considering both within-class switches and different mechanisms of action based on patient response.
• Switching within the same class may be appropriate for partial response or tolerability issues, while a different mechanism is advised for complete lack of efficacy.
• Clinicians should monitor disease activity and patient response closely, ensuring timely intervention and adaptation to therapeutic changes.
• Continuous education and collaboration with multidisciplinary teams are vital for optimizing patient outcomes in multiple sclerosis management.