NeurologyLive® Friday 5 — April 3, 2026

Welcome to NeurologyLive^®'s Friday 5! Every week, the staff compiles 5 highlights of NeurologyLive's widespread coverage in neurology, ranging from newsworthy study findings and FDA action to expert interviews and peer-to-peer panel discussions.

Click the read more or watch now buttons for more details and information about each highlight.

1: From Trial to Practice: How the 2024 Criteria Perform in Real-World Settings

In this episode of our latest NeurologyLive Roundtable Discussion, Adnan Subei, DO, FAAN, Lilyana Amezcua, MD, and Samantha Roman, MD, reviewed emerging real-world and ECTRIMS data demonstrating that the updated McDonald criteria improve earlier MS diagnosis. [WATCH TIME: 6 minutes]

2: Personalizing Treatment Decision-Making in Multiple Sclerosis Care: Constance V. Katsafanas, DO

In honor of National MS Awareness Month, held each March, Constance V. Katsafanas, DO, director of the Neurology Residency Program at the Marcus Neuroscience Institute, detailed the importance of tailoring treatment to patients with multiple sclerosis. [WATCH TIME: 5 minutes]

3: What Clinicians Should Know About Extended Dosing of Pegunigalsidase Alfa

In a recent Q&A, Rachele Berria, MD, PhD, Medical Affairs at Chiesi Global Rare Diseases, discussed the clinical data and implications of newly approved every-4-week dosing of pegunigalsidase alfa for Fabry disease in Europe.

4: Understanding the History Behind Down Syndrome and Dementia

In honor of National Down Syndrome Awareness Day, this new feature discussed how adults with Down syndrome face a high lifetime risk of early-onset Alzheimer disease linked to the triplication of chromosome 21, driving ongoing clinical investigations into therapies for this population.

5: Positioning Gene Therapy in SMA: Insights From 64-Week STEER Study Outcomes

In a recent Q&A, Nazem Atassi, MD, SVP and Global Development Head of Neurology & Gene Therapy at Novartis, discussed 64-week STEER data and the evolving role of one-time gene therapy in spinal muscular atrophy care.

Click here to view our latest video shorts with neurology experts.