Using Artificial Intelligence Algorithms to Predict Seizure Control Following Brain Surgery: Lara Jehi, MD, MHCDS
The epilepsy specialist and Cleveland Clinic’s Chief Research and Information Officer provided clinical background on a promising study employing a machine learning algorithm to predict post-operative seizure outcomes using a peri-ictal scalp EEG. [WATCH TIME: 6 minutes]
WATCH TIME: 6 minutes
"The attractive thing with scalp EEG is that this is the bread and butter of evaluating any patient with epilepsy, anywhere. So every patient who is getting epilepsy surgery is going through that procedure. If we can learn anything from a scalp EEG, whatever that knowledge is, it will be generalizable and helpful to the population at large. That’s what drove this study."
For years, surgical brain resection has been a promising approach for patients with drug-resistant epilepsy (DRE); however, only about half who undergo a procedure achieve sustained seizure freedom. Identifying those who are likely to experience recurrent seizures after resection has been a challenge thus far for clinicians and researchers alike. Previously conducted preclinical data from members at the
A follow-up study, published recently in Nature, highlighted the predictability of a machine learning model-building experiment that used 5 minutes of a peri-ictal scalp EEG data. The study, which included 294 surgical patients who underwent temporal lobe resection for seizures, showed that this approach was successful in making accurate predictions of postoperative seizure outcomes, demonstrated by area under the operating receiver curve of 0.98. In the study, a decision curve analysis also showed that compared with the prevalent clinical-variable based nomogram, use of the EEG-augmented approach could decrease the rate of unsuccessful brain resections by 20%.
Following the publication, study investigator
REFERENCE
1. Sheikh SR, McKee ZA, Ghosn S, et al. Machine learning algorithm for predicting seizure control after temporal lobe resection using peri-ictal. Nature. 2024(14):21771. doi:10.1038/s41598-024-72249-7
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