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Jennifer S. Sun, PhD

Staff Scientist, Sanjana Lab, New York Genome Center, and NYU

Articles

Endoplasmic Reticulum and/or Mitochondrial-Dependent Neuronal Degeneration in ALS

June 14, 2022

Given the importance of mitochondrial and endoplasmic reticulum function in ALS, the disruption of intracellular mitochondria-endoplasmic reticulum contacts presents yet another avenue for neuronal degeneration—perhaps the primary point of underlying dysfunction.

PDE10A Inhibition in Tourette Syndrome

April 19, 2022

Despite progress in the understanding of Tourette syndrome and similar disorders, no clear cause of TS has been identified, nor are there treatment options that completely eliminate symptoms.

Stimulation Approaches to Epilepsy Treatment

February 15, 2022

With one-third of the 3.4 million US patients with epilepsy currently experience drug-resistant epilepsy, creating an urgent need for novel intervention strategies, such as stimulation approaches.

Serotonin Receptor Agonism in Dravet Syndrome

December 21, 2021

As Dravet syndrome is often nonresponsive to existing therapeutics, it can be a challenge to treat, and this refractory nature creates a great need for novel, innovative, and safe antiepileptic drugs for its treatment.

S1P Receptor Modulation in Multiple Sclerosis

October 30, 2021

Continued improvement in the pharmacodynamics and pharmacokinetics of S1PR modulators, particularly in modulator-receptor selectivity, should improve therapeutic efficacy while reducing the potential for AEs.

Myostatin Inhibition in Amyotrophic Lateral Sclerosis

June 16, 2021

ALS has only recently been associated with causative or disease-modifying mutations in 20 genes that encode proteins with diverse functions, with promising therapeutic targets including proteins in pathways that regulate protein homeostasis.