Staff Scientist, Sanjana Lab, New York Genome Center, and NYU
Aβ Protofibril Elimination in Alzheimer DiseaseJanuary 21st 2023
One model of AD suggests that Aβ pathophysiology triggers downstream molecular pathways, including tauopathy, which lead to cortical neurodegeneration, and cognitive decline is further attributed to the associated neurocortical Aβ plaques.
Endoplasmic Reticulum and/or Mitochondrial-Dependent Neuronal Degeneration in ALSJune 14th 2022
Given the importance of mitochondrial and endoplasmic reticulum function in ALS, the disruption of intracellular mitochondria-endoplasmic reticulum contacts presents yet another avenue for neuronal degeneration—perhaps the primary point of underlying dysfunction.
Myostatin Inhibition in Amyotrophic Lateral SclerosisJune 16th 2021
ALS has only recently been associated with causative or disease-modifying mutations in 20 genes that encode proteins with diverse functions, with promising therapeutic targets including proteins in pathways that regulate protein homeostasis.