Dementia and Alzheimer Disease

This is the first large late-stage clinical trial to further support the amyloid hypothesis.

The SPRINT MIND trial found a statistically significant lower rate of new cases of mild cognitive impairment in the intensive treatment group.

The psychiatry and pharmacology professor spoke about the results from the first clinical trial that showed that a cannabinoid can decrease agitation in Alzheimer disease.

A new study has found that an RNA-binding protein called TDP-43 could be a promising new biomarker for diagnosing amyotropic lateral sclerosis.

Efficacy was demonstrated in this patient population at the primary endpoint of 6 weeks, especially in those with more severe baseline NPI-NH-PS.

The recommendations will provide an important tool to help improve the quality of the diagnostic process, so patients receive an early and accurate diagnosis.

Data from an interim analysis of the lumateperone large phase III clinical trial for agitation in subjects with dementia is expected by the end of 2018.

These guidelines will provide primary clinicians and the specialist community an important new tool to more accurately diagnose patients.

The FDA has granted a Breakthrough Device Designation to the Elecsys beta-Amyloid (1-42) and Elecsys Phospho-Tau (181P) cerebrospinal fluid assays, which can be used in the diagnosis of Alzheimer disease.

A prospective cohort study of patients offered amyloid PET as part of their dementia work-up. The results here.

TNX-102 SL’s impact on sleep disturbance highlights a mechanism of action that could result in positive effects on agitation in AD.

More and more, modern medicine is recognizing the influence of diet on good health. Now, research shows that eating a diet rich in vegetables, fruits, nuts, and fish may result in larger total brain volumes and thereby better long-term brain health.

The anti-amyloid protofibril antibody achieved statistical significance in its key efficacy endpoints after 18 months.

A limitation of many supplements is that they are poorly absorbed into the bloodstream after ingestion. A new study used a form of curcumin that had high bioavailability to test its effectiveness in protecting cognition.

The aim of a randomized controlled trial was to see if aerobic and strength training can successfully slow cognitive decline. The results might surprise you.

A study examined the effects of resistance training, aerobic exercise, mind-body, or any combination of these exercises on cognitive function in older adults.

A large study reveals a quality diet leads to larger brain tissue volumes, suggesting that nutrition has an effect on neurodegeneration via brain structure.

New research highlights prevention, diagnostic, and treatment advances for Alzheimer, autism, atherosclerosis, and more.

5 key facts about cerebral microbleeds and risk of future cognitive impairment.

The clinical director of the Anti-NMDA Receptor Encephalitis Foundation spoke about the insidiousness of AD and the need for diagnosis earlier in disease progression.

The presence of REM Behavior Disorder predicted an increased risk of Parkinson disease, Lewy Body dementia, or multisystem atrophy in the largest study ever performed in people with the strange disorder. Details here. 

It looks like research is starting to support exercise as a reliable strategy to prevent dementia.

The finger displacement sign is a simple bedside test that can help distinguish Parkinson dementia from Alzheimer dementia.

When and why were the Beers criteria set in place? Learn more in this quiz.

Here: the most notable changes in the new AAN guideline on mild cognitive impairment.