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In this fifth episode, Cohen explained the types, risks, and monitoring protocols for ARIA with antiamyloid antibodies, emphasizing MRI schedules, symptom vigilance, and individualized patient safety considerations. Supported by Eli Lilly. 

Monitoring and Managing ARIA in Antiamyloid Treatments 

Articles

The VP of clinical development at Alkermes detailed phase 2 results for alixorexton, an oral, selective orexin 2 receptor agonist, in narcolepsy type 1, including benefits for fatigue, cognition, and weakness.

NeuroVoices: Marcus Yountz, on the Promise and Phase 2 Data of Orexin Agent Alixorexton

Catch up on any of the neurology news headlines you may have missed over the course of August 2025, compiled all into 1 place by the NeurologyLive® team.

FDA Action Update, August 2025: Approvals and Complete Response Letter

Phase 3 trial results reveal EPX-100's safety and tolerability in Dravet syndrome, supporting its potential as an effective adjunctive therapy.

Phase 3 Argus Interim Data Support Safety of EPX-100 as Adjunctive Therapy for Dravet Syndrome

Co-director, Jane and John Justin Neurosciences Center, Cook Children’s Hospital

Experts noted that the Lennox-Gastaut syndrome Foundation is a welcoming platform for collaboration, research advancement, and career development in the field. [WATCH TIME: 3 minutes] 

2025 LGS Meeting Reflections and Engagement Opportunities in Research

Experts discussed strategies to improve LGS clinical trial design, better understand comorbidities in rare epilepsies, and foster collaboration across stakeholders. [WATCH TIME: 5 minutes]

Enhancing Design of LGS Clinical Trials and Patient Care in Rare Epilepsies

Experts discussed gaps in LGS research, including biomarker development, sleep assessment, and early intervention strategies to improve diagnosis and outcomes for patients. [WATCH TIME: 6 minutes]

Research Priorities and Clinical Insights in Lennox-Gastaut Syndrome

Experts underscored that stakeholder collaboration, including clinicians, caregivers, and industry partners, can play a critical role in advancing understanding and management of LGS. [WATCH TIME: 3 minutes]

Enhancing Clinical Management of LGS Through Collaboration With Stakeholders

NeurologyLive is your direct connection to the latest neurology news and interviews with expert neurologists in multimedia formats.

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Treatment and Management of Mild-to-Moderate Multiple Sclerosis

Defining Mild Multiple Sclerosis

Video content above is prompted by the following:

How do you determine that the patient has mild or moderate MS?

Prognostic factors, imaging, and brain reserve in mild MS

In a panel discussion, multiple sclerosis (MS) experts Stephen Krieger, MD; Heidi Crayton, MD; Jacqueline Nicholas, MD, PhD; Patricia Coyle, MD, and Enrique Alvarez, MD, PhD, share their insights on current MS therapies, aspirations for guideline revisions, the importance of shared decision-making, and the role of medium-efficacy therapy in the management of mild-to-moderate MS.

Key opinion leaders provide insights into the prevalence and incidence of clinically isolated syndrome (CIS) within their clinical practice.

Presentation of Clinically Isolated Syndrome/First Attack of Multiple Sclerosis

The panelists explore diagnostic methods for differentiating between mild and moderate multiple sclerosis (MS) while also examining prognostic factors, the role of imaging, and the concept of brain reserve in mild MS cases.

Multiple sclerosis (MS) specialists discuss their observations regarding variations in MS presentation and progression among patients of Different Races and Ethnicities

Mild/Moderate Multiple Sclerosis in Patients of Different Races and Ethnicities

The expert panel examines early multiple sclerosis (MS) and patients with mild MS even in later stages of the disease, emphasizing crucial information to convey to patients throughout their journey; faculty also explore cases where disease-modifying therapies (DMTs) may not be utilized.

Conversations With Patients About Mild/Moderate Multiple Sclerosis

The key opinion leaders provide recommendations on the optimal frequency for evaluating disease progression in patients with mild to moderate MS, emphasizing effective monitoring methods and the most appropriate tools for best clinical practice.

Monitoring Patients With Mild/Moderate Multiple Sclerosis

The panel reflects on their experiences as practicing clinicians, emphasizing the significance of shared decision-making and actively listening to patients’ preferences regarding management of their MS. 

Shared Decision-Making for Patients With Mild/Moderate Multiple sclerosis

Multiple sclerosis (MS) treatment specialists discuss the challenges associated with the early use of high-efficacy therapy (HET) in patients with mild to moderate MS and delve into the broader debate surrounding the consistent use of HET for managing mild to moderate MS cases.

De-Escalation Strategies and Challenges With the Use of HET in Mild/Moderate Multiple Sclerosis

Key opinion leaders share their approach to treatment sequencing for patients with multiple sclerosis (MS), taking into account comorbidities such as cardiovascular diseases, risk of infection, liver damage, and cancer as well as considering factors like planned pregnancy or advanced age.

Choosing Between Moderate Therapies for Mild/Moderate Multiple Sclerosis

The panel explores factors influencing treatment adherence in multiple sclerosis (MS) patients and highlights the importance of shared decision-making in promoting and maintaining patient adherence to their prescribed therapy.

Treatment Adherence in Mild Multiple Sclerosis

Medical experts debate the concept of benign multiple sclerosis (MS), questioning whether this subtype truly exists or if it is a misnomer in the context of the disease's long-term progression and impact on patients.

Benign Multiple Sclerosis

The panel identifies and discusses the unmet needs of patients with mild to moderate multiple sclerosis (MS), highlighting areas where current treatment options and management strategies fall short in addressing the unique challenges faced by this patient population.

Diagnostic Uncertainty, Monitoring and Other Unmet Needs in Mild/Moderate Multiple Sclerosis

Key opinion leaders explore the impact of newly available biosimilars and generic biologics for managing multiple sclerosis (MS), discussing how these developments have altered patient access to treatments and the implications for the future of the MS treatment landscape.

Generics and Biosimilars in Multiple Sclerosis

Key opinion leaders examine the available data on Bruton tyrosine kinase (BTK) inhibitors to assess whether the evidence supports their efficacy as a treatment option for multiple sclerosis (MS).

Emerging Treatments in Mild/Moderate Multiple Sclerosis

In closing, the panel of experts in multiple sclerosis (MS) offer their insights and recommendations for clinicians, emphasizing best practices to optimize patient care and improve overall outcomes in the management of MS.

Final Thoughts on Caring for Patients With Mild/Moderate Multiple Sclerosis

Peer Exchange

 Peer Exchange video series features panels of expert physicians engaging in in-depth discussions about practice-changing treatments, challenges in care, and the future paradigm of management for neurologic diseases.

Defining Mild Multiple Sclerosis

EP: 1.Presentation of Clinically Isolated Syndrome/First Attack of Multiple Sclerosis

EP: 2.Defining Mild Multiple Sclerosis

EP: 3.Mild/Moderate Multiple Sclerosis in Patients of Different Races and Ethnicities

EP: 4.Conversations With Patients About Mild/Moderate Multiple Sclerosis

EP: 5.Monitoring Patients With Mild/Moderate Multiple Sclerosis

EP: 6.Shared Decision-Making for Patients With Mild/Moderate Multiple sclerosis

EP: 7.De-Escalation Strategies and Challenges With the Use of HET in Mild/Moderate Multiple Sclerosis

EP: 8.Choosing Between Moderate Therapies for Mild/Moderate Multiple Sclerosis

EP: 9.Treatment Adherence in Mild Multiple Sclerosis

EP: 10.Benign Multiple Sclerosis

EP: 11.Diagnostic Uncertainty, Monitoring and Other Unmet Needs in Mild/Moderate Multiple Sclerosis

EP: 12.Generics and Biosimilars in Multiple Sclerosis

EP: 13.Emerging Treatments in Mild/Moderate Multiple Sclerosis

EP: 14.Final Thoughts on Caring for Patients With Mild/Moderate Multiple Sclerosis

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