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Articles

West Nile virus poses increasing neurologic risks in the US, with new strains emerging and significant health implications for vulnerable populations.

Concern Over Neuroinvasive Infections Rises as CDC Confirms First US Case of West Nile Virus Lineage 3 

New findings showed that adjunctive VNS therapy led to sustained reductions in generalized tonic-clonic seizure frequency, supporting its long-term efficacy in patients with drug-resistant epilepsy.

LivaNova’s VNS Therapy Maintains Effectiveness in Drug-Resistant Epilepsy in Latest 2-Year Data

Videos

The associate professor of psychiatry and human behavior at UC Irvine explored how analyzing specific sleep oscillations may uncover early neurodegenerative changes and guide future therapeutic targets. [WATCH TIME: 4 minutes]

Oscillations in Non-REM Sleep Offer New Insight Into Alzheimer Disease Biology: Bryce Mander, PhD

Exablate Neuro is a noninvasive, MRI-guided focused ultrasound technology designed to treat targeted brain areas without incisions or implanted hardware, offering a lower-risk alternative to traditional surgery.

Exablate Neuro Gains FDA Approval for Staged Bilateral Focused Ultrasound in Advanced Parkinson Disease 

Marco Meglio, Assistant Managing Editor for 

, has been with the team since October 2019. Follow him on Twitter 

Laren Becker, MD, PhD, a physician-scientist at Stanford University, discussed how gastrointestinal dysfunction and peripheral dopaminergic activity impact Parkinson disease treatment and progression.

Recognizing Gastrointestinal Symptoms as Early Indicators of Parkinson Disease

Continuous subcutaneous apomorphine infusion significantly reduces OFF episodes and enhances ON time in Parkinson's disease patients, improving overall health status.

Reduction in Parkinson OFF Episodes Through Subcutaneous Apomorphine Infusion Leads to Doubling of Good ON Time

Nurse practitioner in the Center for Movement Disorders & Neurorestoration at the University of Florida.

The nurse practitioner in the Center for Movement Disorders & Neurorestoration at the University of Florida discussed a complex case of childhood-onset dystonia treated with DBS. [WATCH TIME: 6 minutes]

Revisiting Deep Brain Stimulation in a Pediatric-Onset Dystonia Case: Pamela Zeilman, NP

, has been with the team since September 2022. Follow her on Twitter 

A physician assistant specializing in Parkinson disease shared key clinical considerations for selecting and educating patients about on-demand therapies for the movement disorder.

NeuroVoices: Cheryl Kyinn, PA-C, on Personalizing On-Demand Therapies for OFF Episodes in Parkinson Disease

NeurologyLive is your direct connection to the latest neurology news and interviews with expert neurologists in multimedia formats.

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Treatment and Management of Mild-to-Moderate Multiple Sclerosis

Diagnostic Uncertainty, Monitoring and Other Unmet Needs in Mild/Moderate Multiple Sclerosis

What are unmet needs for patients with mild or moderate MS?

Diagnostic uncertainty in the mild disease

Monitoring for subtle progression in these patients

In a panel discussion, multiple sclerosis (MS) experts Stephen Krieger, MD; Heidi Crayton, MD; Jacqueline Nicholas, MD, PhD; Patricia Coyle, MD, and Enrique Alvarez, MD, PhD, share their insights on current MS therapies, aspirations for guideline revisions, the importance of shared decision-making, and the role of medium-efficacy therapy in the management of mild-to-moderate MS.

Key opinion leaders provide insights into the prevalence and incidence of clinically isolated syndrome (CIS) within their clinical practice.

Presentation of Clinically Isolated Syndrome/First Attack of Multiple Sclerosis

The panelists explore diagnostic methods for differentiating between mild and moderate multiple sclerosis (MS) while also examining prognostic factors, the role of imaging, and the concept of brain reserve in mild MS cases.

Defining Mild Multiple Sclerosis

Multiple sclerosis (MS) specialists discuss their observations regarding variations in MS presentation and progression among patients of Different Races and Ethnicities

Mild/Moderate Multiple Sclerosis in Patients of Different Races and Ethnicities

The expert panel examines early multiple sclerosis (MS) and patients with mild MS even in later stages of the disease, emphasizing crucial information to convey to patients throughout their journey; faculty also explore cases where disease-modifying therapies (DMTs) may not be utilized.

Conversations With Patients About Mild/Moderate Multiple Sclerosis

The key opinion leaders provide recommendations on the optimal frequency for evaluating disease progression in patients with mild to moderate MS, emphasizing effective monitoring methods and the most appropriate tools for best clinical practice.

Monitoring Patients With Mild/Moderate Multiple Sclerosis

The panel reflects on their experiences as practicing clinicians, emphasizing the significance of shared decision-making and actively listening to patients’ preferences regarding management of their MS. 

Shared Decision-Making for Patients With Mild/Moderate Multiple sclerosis

Multiple sclerosis (MS) treatment specialists discuss the challenges associated with the early use of high-efficacy therapy (HET) in patients with mild to moderate MS and delve into the broader debate surrounding the consistent use of HET for managing mild to moderate MS cases.

De-Escalation Strategies and Challenges With the Use of HET in Mild/Moderate Multiple Sclerosis

Key opinion leaders share their approach to treatment sequencing for patients with multiple sclerosis (MS), taking into account comorbidities such as cardiovascular diseases, risk of infection, liver damage, and cancer as well as considering factors like planned pregnancy or advanced age.

Choosing Between Moderate Therapies for Mild/Moderate Multiple Sclerosis

The panel explores factors influencing treatment adherence in multiple sclerosis (MS) patients and highlights the importance of shared decision-making in promoting and maintaining patient adherence to their prescribed therapy.

Treatment Adherence in Mild Multiple Sclerosis

Medical experts debate the concept of benign multiple sclerosis (MS), questioning whether this subtype truly exists or if it is a misnomer in the context of the disease's long-term progression and impact on patients.

Benign Multiple Sclerosis

The panel identifies and discusses the unmet needs of patients with mild to moderate multiple sclerosis (MS), highlighting areas where current treatment options and management strategies fall short in addressing the unique challenges faced by this patient population.

Key opinion leaders explore the impact of newly available biosimilars and generic biologics for managing multiple sclerosis (MS), discussing how these developments have altered patient access to treatments and the implications for the future of the MS treatment landscape.

Generics and Biosimilars in Multiple Sclerosis

Key opinion leaders examine the available data on Bruton tyrosine kinase (BTK) inhibitors to assess whether the evidence supports their efficacy as a treatment option for multiple sclerosis (MS).

Emerging Treatments in Mild/Moderate Multiple Sclerosis

In closing, the panel of experts in multiple sclerosis (MS) offer their insights and recommendations for clinicians, emphasizing best practices to optimize patient care and improve overall outcomes in the management of MS.

Final Thoughts on Caring for Patients With Mild/Moderate Multiple Sclerosis

Peer Exchange

 Peer Exchange video series features panels of expert physicians engaging in in-depth discussions about practice-changing treatments, challenges in care, and the future paradigm of management for neurologic diseases.

Diagnostic Uncertainty, Monitoring and Other Unmet Needs in Mild/Moderate Multiple Sclerosis

EP: 1.Presentation of Clinically Isolated Syndrome/First Attack of Multiple Sclerosis

EP: 2.Defining Mild Multiple Sclerosis

EP: 3.Mild/Moderate Multiple Sclerosis in Patients of Different Races and Ethnicities

EP: 4.Conversations With Patients About Mild/Moderate Multiple Sclerosis

EP: 5.Monitoring Patients With Mild/Moderate Multiple Sclerosis

EP: 6.Shared Decision-Making for Patients With Mild/Moderate Multiple sclerosis

EP: 7.De-Escalation Strategies and Challenges With the Use of HET in Mild/Moderate Multiple Sclerosis

EP: 8.Choosing Between Moderate Therapies for Mild/Moderate Multiple Sclerosis

EP: 9.Treatment Adherence in Mild Multiple Sclerosis

EP: 10.Benign Multiple Sclerosis

EP: 11.Diagnostic Uncertainty, Monitoring and Other Unmet Needs in Mild/Moderate Multiple Sclerosis

EP: 12.Generics and Biosimilars in Multiple Sclerosis

EP: 13.Emerging Treatments in Mild/Moderate Multiple Sclerosis

EP: 14.Final Thoughts on Caring for Patients With Mild/Moderate Multiple Sclerosis

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