Integrated Neuro-Oncology Care: Management Strategies for Paraneoplastic Neurologic Syndromes

WATCH TIME: 4 minutes | Captions are auto-generated and may contain errors.

This clinical video series, titled “Crossroads in Neuro-Oncology: Understanding Paraneoplastic Neurologic Syndromes,” is a NeurologyLive^® Roundtable Discussion focused on the recognition and management of paraneoplastic neurologic syndromes (PNS) in patients with cancer. These immune mediated neurologic disorders can present across the cancer continuum and may cause rapid functional decline, underscoring the importance of early identification, appropriate diagnostic evaluation, and coordinated multidisciplinary care.

In collaboration with Northwestern Medicine, neuro-oncology experts Shailee Samir Shah, MD, clinical assistant professor of neurology, and Ditte Primdahl, MD, assistant professor of neurology, joined host Jax DiEugenio to provide a clinical overview of PNS. The discussion covered real-world presentation patterns, diagnostic considerations, screening protocols, and patient selection criteria. The experts also evaluate modern therapeutic interventions and practical management strategies while exploring the evolving treatment landscape for PNS.

In this fifth episode, Shah and Primdahl discussed integrated neuro-oncology management strategies for PNS in the setting of active cancer treatment. They reviewed best practices for initiating immunomodulatory therapy, examined clinical factors that may predict neurologic responsiveness to immunotherapy or immunosuppression, and explained how early neuro-oncology involvement can meaningfully influence functional outcomes and quality of life. The discussion also highlighted the importance of coordinated supportive and rehabilitative care in addressing long-term neurologic sequelae, providing a practical framework for optimizing multidisciplinary management of PNS.

Click here to watch more episodes of this video series.