Results from the Subgroup Analysis of BECOME Caregiver Survey: Robert Iannone, MD, MSCE
The executive vice president of Global Head of Research and Development at Jazz Pharmaceuticals, spoke on the results from the BECOME study presented at the 2022 AES Conference. [WATCH TIME: 6 minutes]
WATCH TIME: 6 minutes
“Epilepsy in the context of the syndromes for which Epidiolex (cannabidiol) has been approved, is a complex set of not only seizures, but other comorbidities that have to do with communication, socialization and cognition. It's important to continue to study these aspects to really understand how to optimize the benefit of Epidiolex and any antiseizure medication.”
Recently, a global outcomes survey, BEhavior, Cognition, and More with Epidiolex®, orBECOME, of caregivers of patients with Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS), reported improvements in seizure frequency and severity with use of cannabidiol (CBD; Epidiolex; Jazz Pharmaceuticals). The findings from the analysis provided clarification of the effects of the FDA-approved treatment in pediatric patients in comparison with adults(aged younger than 18 years and aged older than or 18 years). The results were presented as a late breaker in a poster session at the
Results showed that most respondents from both groups reported any improvements in seizure frequency (84% each) and severity (pediatric, 77% and adults, 75%). Also, both groups reported decreases in convulsive seizures (72% each), drop seizures (71% each), nonconvulsive/nondrop seizures (pediatric, 66% and adults, 69%), and nighttime seizures (pediatric, 61% and adults, 63%). Notably, both groups had reports of improvements in seizure-free days per week (pediatric, 65% and adults, 70%) and seizure freedom in the past month (pediatric, 18% and adults, 15%).
REFERENCES
1. Saurer T, Berg A, Dixon-Salazar T, et al. Seizure Outcomes with Cannabidol (CBD) in Pediatric Patients Versus Adult Patients with Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS): Subgroup Analysis of BECOME Caregiver Survey Results. Presented at: AES Annual Meeting; December 2-6, 2022; Nashville, TN, and virtual. Late Breaker Poster.
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