Dementia and Alzheimer Disease

Suvorexant improved the mean total sleep time by 28.2 minutes for the patients receiving the treatment versus placebo, equating to a mean increase of 73.4 minutes with the orexin receptor antagonist.

The chief medical officer and head of Research & Development at Ovid Therapeutics spoke about the Visual Analog Scale that the company developed to help better understand the impact that potential treatments have on patients with Fragile X syndrome.

The post hoc analysis pooled data from 3 trials to evaluate the benefits of adding memantine to treatment with cholinesterase inhibitors for patients with moderate to severe Alzheimer disease.

The report includes consensus-based recommendations, which consist of guidelines for the diagnosis and staging of LATE-neuropathological change—defined by stereotypical TDP-43 proteinopathy both with or without simultaneous hippocampal sclerosis pathology, in older adults.

Researchers found that cognitively unimpaired patients with apneas had an average of 4.5% higher levels of tau in the entorhinal cortex than those who did not have apneas, after controlling for several other factors.

A prospective case controlled study looked at the relationship of retinal blood flow and vessel density to early onset Alzheimer disease and mild cognitive impairment.

The adoption of plasma NfL as a biomarker for tracking neurodegeneration would help fill a need for a less invasive, more economical biomarker.

What do you suspect is responsible for this patient’s progressively worsening cognitive symptoms?

NeurologyLive spoke with the director of the Cleveland Clinic Lou Ruvo Center for Brain Health to learn why, despite hundreds of failed trials and therapies, there is growing excitement for what's to come.

Research from the past decade suggests that sigma-1 receptors and their encoding gene, SIGMAR1, together act as a therapeutic target for patients with dementia.

Responses from 1300 physicians suggest that increasing patient load and adding ancillary services may be the key to increasing annual income.

The PEGASUS principal investigator and Translational Neurology Head of the Interdisciplinary Brain Center at Massachusetts General Hospital and Harvard Medical School spoke about the Amylyx Pharmaceuticals product’s potential in Alzheimer.

Obstructive sleep apnea may affect the accumulation of tau in the brain.

The differential diagnosis of frontotemporal dementia is complicated by its heterogenous clinical presentation, with symptoms that overlap with several other dementias.

Amylyx Pharmaceuticals announced the trial of the 2-drug combination is seeking to enroll 100 patients with late-stage mild cognitive impairment or dementia due to Alzheimer, with plans to complete the study in 2020.

Patient management 90 days after amyloid PET changed in 60.2% of patients with MCI and 63.5% of patients with dementia of uncertain etiology.

Neurology News Network for the week of March 30, 2019.

Treatment with AVP-786 in TRIAD-1 showed a significant improvement on the primary endpoint on the Cohen-Mansfield Agitation Inventory for 1 of the 2 doses being evaluated.

The panel voted 14 to 0 against granting de novo clearance to the device.