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Test your neurology knowledge with NeurologyLive®'s weekly quiz series, featuring questions on a variety of clinical and historical neurology topics. This week's topic is on the link between iRBD and neurodegeneration.

NeurologyLive® Brain Games: August 31, 2025

Videos

The director of the Adult Genetic Epilepsy Program at the University of Toronto talked about how to ensure a smooth transition from pediatric to adult epilepsy care for university students. [WATCH TIME: 4 minutes]

Back to School, Transitioning College Students With Epilepsy to Adult Care: Danielle Andrade, MD, MSc, FRCPC

Neurology News Network. for the week ending August 30, 2025. [WATCH TIME: 4 minutes]

Efgartigimod Meets End Point in Seronegative Myasthenia Gravis Study, Cemdisiran Submission for MG Coming Soon, Phase 3 Studies of IncobotulinumtoxinA Begin

The autoinjector, branded as Leqembi Iqlik, contains a 360 mg/1.8 mL dose administered over 15 seconds. It is expected to enhance Alzheimer treatment accessibility and offer cost savings for patients.

FDA Approves Lecanemab Autoinjector, Marking First At-Home Treatment for Alzheimer Disease

The director of the Norman Fixel Institute for Neurological Diseases at UF Health talked about prevention, understanding disease mechanisms, and creating a patient-centered care model in Parkinson disease. [WATCH TIME: 5 minutes]

Focusing on Prevention and Patient-Centered Care in Parkinson Disease: Michael S. Okun, MD

Marco Meglio, Assistant Managing Editor for 

, has been with the team since October 2019. Follow him on Twitter 

The neurophysiologist at Allegheny Health Network shared his clinical experience with tofersen in patients with SOD-1 ALS, while emphasizing the critical role of accessible genetic testing for patient identification. [WATCH TIME: 3 minutes]

Clinical Experience and Considerations With ALS Medication Tofersen: Sandeep Rana, MD

The vice chair of education for the department of neurology at Mass General outlined her AUPN 2025 session on supporting clinician educators through recognition, career development, and institutional frameworks for advancement. [WATCH TIME: 4 minutes]

Building Better Pathways for Clinician Educators in Academic Neurology: Tamara Kaplan, MD

The director of the Norman Fixel Institute for Neurological Diseases at UF Health highlighted the need for equitable, worldwide access to levodopa for patients with Parkinson disease. [WATCH TIME: 6 minutes]

A Global Calling for Universal Levodopa Access in Parkinson Disease Treatment: Michael S. Okun, MD

NeurologyLive is your direct connection to the latest neurology news and interviews with expert neurologists in multimedia formats.

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Clinical

 Narcolepsy Disease Spotlight page offers specific updates and coverage on the latest expert conversations and data readouts related to the treatment and management of patients with the sleep disorder.

 to subscribe on your favorite streaming service.

The Mind Moments podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis, Parkinson disease, dementia, sleep disorders, and more.

In this episode, "Sleep and Seizures: Emerging Insights from AAN 2025," Nancy Foldvary-Schaefer, DO, director of the Sleep Disorders Center at 

, reflected on key sleep-related topics presented at this year’s 

American Academy of Neurology (AAN) Annual Meeting

. She highlighted the growing clinical interest in underrecognized conditions like idiopathic hypersomnia and narcolepsy, stressing the need for better awareness and earlier diagnosis. Foldvary-Schaefer also detailed the development of the Sleep by Cleveland Clinic mobile app, designed to improve screening for common sleep disorders with validated tools and real-time resources. Additionally, she discussed new findings on the prevalence of obstructive sleep apnea in adults with epilepsy, pointing to the importance of routine sleep screening in this population, regardless of seizure severity. Finally, she shared exploratory data on SSRI use and peri-ictal respiratory patterns in epilepsy, offering new perspectives on potential protective mechanisms tied to SUDEP risk.

The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

FDA Approves Pre-Filled Syringe Administration for FcRn Modulator Efgartigimod

FDA Approves CT-132 as First Digital Therapeutic for Preventive Treatment of Episodic Migraine

FDA Expands Diazepam Nasal Spray Indication to Treat Ages 2 to 5

 – Key sleep topics discussed at AAN 2025 and the growing interest in hypersomnia

 – Development and purpose of the SLEEP mobile app by Cleveland Clinic

 – Findings on obstructive sleep apnea prevalence in adults with epilepsy

 – The need for sleep disorder screening in epilepsy clinical trials

 – Exploratory findings on SSRI use and respiratory patterns in patients with epilepsy

 to subscribe to the Mind Moments podcast. Be sure to leave a rating and review for the show. Thanks for listening!

Hoping to listen on your favorite podcast app? See below:

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Nancy Foldvary-Schaefer, DO, FAAN. [LISTEN TIME: 25 minutes]

Episode 139: Sleep and Seizures: Emerging Insights From AAN 2025

In this episode, "Invaluable Role of Social Support in Narcolepsy and Idiopathic Hypersomnia Care," Julie Flygare, JD, president and chief executive officer of Project Sleep, shared her personal and professional insights into the critical role of social connections for patients living with sleep disorders. Drawing from her journey with narcolepsy, Flygare highlighted the challenges of isolation at diagnosis and the transformative power of peer support and advocacy. She delved into survey findings that underscore the rarity of social connections among patients and their impact on adjustment and well-being. Additionally, Flygare offered actionable recommendations for clinicians to integrate social support into practice, emphasizing the value of patient advocacy organizations and fostering meaningful connections. Above all, her inspiring perspective shed light on the intersection of community, research, and clinical care in sleep health.

FDA Approves Mirdametinib for NF1-Associated Plexiform Neurofibromas in Adults and Children

FDA Approves Tablet Formulation of Risdiplam for Spinal Muscular Atrophy

Solid Reports Positive Data for SGT-003 Gene Therapy in Phase 1/2 Trial of Duchenne

 – Challenges and importance of social connections

 – Building a thriving community and research impact

 – Insights from patient surveys on social support

 – Recommendations for clinicians on social support

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Julie Flygare, JD. [LISTEN TIME: 16 minutes]

Episode 135: Invaluable Role of Social Support in Narcolepsy and Idiopathic Hypersomnia Care

 podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis (MS), Parkinson disease, dementia, sleep disorders, and more.

This episode, "FDA Approves Sodium Oxybate for Pediatric Narcolepsy," features an exclusive interview with Anne Marie Morse, DO, FAASM, a pediatric sleep disorders specialist, who sat down to discuss the significance of the FDA's expanded indication for sodium oxybate (Lumryz; Avadel Pharmaceuticals) for the treatment of pediatric patients aged 7 years and older with narcolepsy. Morse, director of Child Neurology and Pediatric Sleep Medicine at Geisinger Janet Weis Children's Hospital as well as the program director for Child Neurology Residency Program, provided commentary on the clinical considerations behind this once-nightly formulation of sodium oxybate, and how it should be used going forward. Furthermore, she stressed the careful use of sodium oxybate treatments, noting that they may have significant impact on patients with narcolepsy and should not be only reserved for the most severe cases.

For more of NeurologyLive's coverage of sodium oxybate's expanded approval, head here: 

FDA Approves Avadel's Sodium Oxybate for Cataplexy or Excessive Daytime Sleepiness in Pedatric Narcolepsy

 – Immediate reaction and significance 

 – Considerations and caution with prescribing sodium oxybate

 – Closing remarks and the need to utilize highly effective treatments for narcolepsy

 podcast. Be sure to leave a rating and review for the show. Thanks for listening!

REFERENCES
1. Avadel Pharmaceuticals Announces FDA Approval of LUMRYZ™ (sodium oxybate) Extended-Release Oral Suspension (CIII) for the Treatment of Cataplexy or Excessive Daytime Sleepiness in Patients 7 Years of Age and Older with Narcolepsy. News Release. Avadel Pharmaceuticals. Published October 17, 2024. Accessed October 23, 2024. https://investors.avadel.com/news-releases/news-release-details/avadel-pharmaceuticals-announces-fda-approval-lumryztm-sodium

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Anne Marie Morse, DO, FAASM. [LISTEN TIME: 12 minutes]

Special Episode: FDA Approves Sodium Oxybate for Pediatric Narcolepsy

In this episode, "Understanding the Potential Cardiovascular Benefits of Low-Sodium Oxybate," Phil Jochelson, MD, therapeutic head for Clinical Development Neuroscience at Jazz Pharmaceuticals, sat down to discuss the phase 4 XYLO study, a randomized controlled study evaluating the effects of switching from high-sodium to low-sodium oxybate on blood pressure in patients with narcolepsy. Jochelson gave some insight regarding the conduct of the trial, including end points, objectives, and patient demographics, as well as some of the benefits to studying blood pressure and cardiovascular risks. In addition, he discussed enhancements to narcolepsy care through low-sodium oxybate, the importance of unique studies like XYLO, and the need to educate clinicians on sodium load and its risks.

EU Regulatory Review Adopts Negative Opinion of Lecanemab as Treatment for Alzheimer Disease

GLP-1 Agonist Liraglutide Shows Protective Effects on Alzheimer Disease in Phase 2 Trial

FDA Approves Carbidopa/Levodopa ER Capsules Formulation IPX203 for Parkinson Disease

 – Reasons behind the XYLO study and links between high sodium intake and cardiovascular risk

 – Patient demographics; inclusion and exclusion criterias

 – Overview of XYLO and determining what a successful study looks like

 – Improved understanding of the benefits of low-sodium oxybate

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Phil Jochelson, MD. [LISTEN TIME: 20 minutes]

Episode 121: Understanding the Potential Cardiovascular Benefits of Low-Sodium Oxybate

Episode 110, "Differential Diagnosis of Sleep Disorders and Hypersomnias" features a conversation with Alcibiades Rodriguez, MD, medical director of the Comprehensive Epilepsy Center—Sleep Center at NYU Langone, who discussed several sleep-related topics, including the diagnosis of rare sleep disorders and hypersomnias. He spoke on the treatment of obstructive sleep apnea, the importance of adherence to medication, and the ways clinicians can help patients stick to their treatment regimen. Furthermore, he talked about the conversations between patients and clinicians to ensure an accurate diagnosis, as well as the emerging research in the sleep disorder field over the coming years.


Glatiramer Acetate Depot Demonstrates Sustained Longterm Safety Profile as Potential MS Therapy

Phase 3 DAYBREAK Trial Highlights Long-Term Efficacy of Ozanimod for Relapsing Multiple Sclerosis

SRP-9001 Improves Duchenne Muscular Dystrophy Disease Trajectory Despite Failing to Meet Primary End Point in Phase 3 EMBARK Trial

, a streaming channel from MJH Life Sciences

. Check out new content and shows every day, only at

 – Conversations needed to differentiate diagnoses

 – Appearance of sleep disorders and overlap

 – Complications with untreated sleep apnea

 – Ways to improve adherence to medication

Mind Moments®, a podcast from NeurologyLive®, brings you an interview with Alcibiades Rodriguez, MD. [LISTEN TIME: 19 minutes]

Episode 110: Differential Diagnosis of Sleep Disorders and Hypersomnias

Episode 104, "Effects of Once-Nightly Sodium Oxybate on Narcolepsy Types 1 and 2" features an interview with Jennifer Gudeman, PharmD, senior vice president of medical and clinical affairs for Avadel Pharmaceuticals, who discussed a recently published post-hoc analysis of the phase 3 REST-ON trial of once-nightly sodium oxybate (Lumryz). In the conversation, Gudeman talked about the impact of the drug on both narcolepsy types 1 and 2, the differences between these 2 subtypes, and the ways clinical trials of narcolepsy agents continue to evolve. Furthermore, she spoke on some of the unmet needs for this patient population, including lingering brain fog and overcoming negative stigmas.

FDA Places Clinical Hold on Roche’s BTK Inhibitor Fenebrutinib for Multiple Sclerosis

ALS Candidate PrimeC Meets Primary Safety and Secondary End Points in Phase 2b PARADIGM Study

FDA Clears NeuroOne’s OneRF Ablation System for Neurosurgerical Procedures

 – Overview of post-hoc analysis of REST-ON

– Differences in type 1 and 2 narcolepsy

– Expanding treatment profile of once-nightly sodium oxybate

– Lingering unmet needs of patients with narcolepsy

 – Realistic timeline of gene therapies for epilepsy

– Future of narcolepsy research, drug development trials

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Jennifer Gudeman, PharmD. [LISTEN TIME: 17 minutes] 

Episode 104: Effects of Once-Nightly Sodium Oxybate on Narcolepsy Types 1 and 2

Episode 98, "Uncovering Phenotypical Features of Narcolepsy Type 1" Features an interview with Birgitte R. Kornum, MD, an associate professor in the department of neuroscience at the University of Copenhagen, who discussed recently published preclinical research assessing phenotypical features and disease progression of narcolepsy type 1. Kornum provided insight on the 2 mouse models used, the effectiveness of the DVC System, and some of the phenotypic features identified. In addition, she gave insight on how the research adds to the ongoing puzzle of treating narcolepsy and where future efforts should be directed toward.

Alzheimer Agent ALZ-801 Improves Cognition, Reduces Relevant Biomarker Levels in 2-Year Analysis

FDA Updates Label for Psychosis Medication Pimavanserin

FDA Approves AI-Incorporated Alzheimer Detection Software AIRAscore

 – Overview of Medicare study and objectives

 – Clinical takeaways from the findings

 – Critical phenotypic features of narcolepsy 

 – Significance of this research, future goals

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Birgitte Kornum, MD. [LISTEN TIME: 18 minutes]

Episode 98: Uncovering Phenotypical Features of Narcolepsy Type 1

Episode 91, "Assessing the Landscape of Sleep Disorder Care," features an exclusive interview with Ann Marie Morse, DO, FAAN, a pediatric neurologist and sleep medicine specialist at Geisinger Medical Center, who sat down with us at the annual SLEEP meeting to discuss the landscape of challenges narcolepsy-related challenges that patients face, the influence of gut health on sleep apnea, and much more.

Biogen and Denali Terminate Phase 3 LIGHTHOUSE Study of BIIB122 in LRRK2-related Parkinson Disease

FibroGen's Duchenne Muscular Dystrophy Antibody Pamrevlumab Falls Short in Phase 3

Phase 2/3 Study of Blarcamesine in Pediatrics With Rett Syndrome Completes Enrollment

FDA Places Hold on Phase 1 Study of Exon Skipping Therapy PGN-EDODM1 in Myotonic Muscular Dystrophy

FDA Panel Votes in Favor of Eisai’s Lecanemab for Early Alzheimer Disease

Post-Marketing Study of Andexanet Alfa Stopped Early After Achieving Prespecified Efficacy

 – Factors at play in obstructive sleep apnea

 – Literature on the gut microbiome's role in sleep

 – Lingering needs in narcolepsy treatment

 – The effect of disrupted nighttime sleep

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Ann Marie Morse, DO, FAAN. [LISTEN TIME: 20 minutes]

Episode 91: Assessing the Landscape of Sleep Disorder Care

 podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis, Parkinson disease, dementia, sleep disorders, and more.

Episode 85, "Impact of Narcolepsy on Social Relationship Health in Adolescents," features an exclusive interview with Eric Zhou, PhD, assistant professor of pediatrics at Harvard Medical School. He spoke on a recently conducted study assessing the link between narcolepsy in adolescents and social relationship health. Specifically, he talked about how the sleep disorder impacts mood, physical activities, driving, and other long-term health outcomes, as well as ways we can help adolescents with narcolepsy at the earliest stages.

FDA to Hold AdComm Meeting for Investigational DMD Treatment SRP-9001

Treg Suppressing Agent COYA 302 Shows Slowing of ALS Disease Progression

FDA Issues Complete Response Letter for AbbVie’s 24-Hour Continuous Carbidopa/Levodopa Pump

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Eric Zhou. [LISTEN TIME: 14 minutes]

Narcolepsy

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