Latest Conference Coverage

Switch to Siponimod Safe, Tolerable With No Washout, Study Finds

Results from the ongoing clinical trial will help define clinical management guidelines for switching patients with relapsing MS on other disease-modifying therapies to siponimod.

Multiple Independent Current Control DBS Associated With Improved Outcomes in Parkinson Disease

No stimulation adverse effects were reported, and patients on the MICC stimulation alone resulted in greater than 50% improvement in UPDRS motor scores.

Simple Interventions Improve Compliance With Patient-Specific Stroke Discharge Instructions

Researchers from Ascension Saint Agnes improved compliance in their hospital in providing patient-specific, stroke-dedicated discharge instructions.

Disparities in Stroke Rehabilitation: Sana Somani, MD, MBBS

The vascular neurology fellow at the University of Maryland Medical Center discussed findings that African American women had the lowest functional performance in stroke rehabilitation.

Rimegepant Safe in Patients With Prior Triptan Failure

Serious adverse events occurred in 3.7% and 2.4% of subjects in the subgroups of patients with 1 and 2 or more triptan failures, respectively.

Role of Social Determinants in Epilepsy Treatment Delays: Joseph Sirven, MD

The professor of neurology at Mayo Clinic discussed the reasoning for the research he presented at AAN 2021 on social determinants and their impact on epilepsy treatment times.

Negative Impacts on Cognition Not Observed With Pimavanserin for Dementia-Related Psychosis

The study presented at the 2021 AAN Meeting follows the complete response letter issued by the FDA to Acadia Pharmaceuticals due to deficiencies in their sNDA.

Improving Stroke Discharge Instructions: Marian LaMonte, MD, MSN, FAAN

The chief of neurology at Ascension Saint Agnes discussed her team’s efforts to increase compliance in providing patient-specific stroke DCI.

Plasma NfL Offers Better Prognostication for Neurodegeneration Than Total Tau

Data from a cohort of more than 900 individuals suggest that while total tau can add cross-sectional value in certain contexts, neurofilament light served better for prognostication of cognitive decline and imaging changes.

Utilizing Aspirin to Lower Stroke Rates in Cerebral Amyloid Antipathy: Sheheryar Jamali, MD

The neurologist from Mayo Clinic discussed his abstract at AAN 2021 comparing stroke rates in patients with cerebral amyloid antipathy given treatment with aspirin.

Investigators Identify Links Between Clinical Seizure Characteristics and Continuous EEG

Critically ill patients who were obtunded, stuporous, or comatose had pediatric lateralized epileptiform discharges, and acute brain insults were among many clinical characteristics to benefit from longer EEG.

Personalized Cladribine Dosing for Multiple Sclerosis

Kimberly Allen-Philbey, a PhD candidate at the Barts MS Center in London, discussed the advantages of using a personalized dosing schedule of off-label, subcutaneous cladribine.

What to Expect from the 2021 American Academy of Neurology Annual Meeting

The 2021 AAN Annual Meeting will be held virtually from April 17-22. Follow along with coverage from NeurologyLive, including expert interviews and session recaps.

Finding New Therapeutic Targets in MS: Daniel Reich, MD, PhD

The senior investigator at the National Institutes of Neurological Disorders and Stroke spoke about further research his lab is conducting into MS mechanisms.

NeuroVoices: Ralph Sacco, MD, MS, on Improving Disparities and Expanding Research in Stroke Care

The chair of neurology and Olemberg Family Chair of Neurological Disorders at the University of Miami Miller School of Medicine discussed solutions to improve disparities in stroke care and the need for future research on social determinants of health.

Treating Paramagnetic Rim Lesions in Multiple Sclerosis

Jemima Akinsanya, DO, Neuroimmunology Clinical Fellow at the National Institutes of Health, discussed new studies of anakinra and tolebrutinib in MS.

Potential Use of DISCO-MS Survey: Anne Kever, PhD

Understanding Mechanisms of MS Chronic Inflammation: Jemima Akinsanya, DO, and Daniel Reich, MD, PhD

The duo from the National Institutes of Health discussed how monitoring and treating paramagnetic rim lesions can improve patient care in multiple sclerosis.

Need for Research on Social Determinants of Health for Stroke Outcomes: Ralph Sacco, MD, MS, FAAN, FAHA

The chair of neurology and Olemberg Family Chair of Neurological Disorders at the University of Miami Miller School of Medicine detailed the reasons behind the lack of research on social determinants of health on stroke outcomes.

Improving Racial and Ethnic Disparities in Stroke Care: Ralph Sacco, MD, MS, FAAN, FAHA

The chair of neurology and Olemberg Family Chair of Neurological Disorders at the University of Miami Miller School of Medicine provided plans of action to reduce racial and ethnic disparities in stroke.

Chariot MS Study of Off-Label Cladribine in Advanced MS: Kimberly Allen-Philbey

The PhD candidate at the Barts MS Center in London discussed the upcoming Chariot MS study as well as further research she would like to conduct in personalized cladribine dosing.

Ways to Lower Genetic Leukodystrophies Misdiagnosis in Clinical Settings: Alise Carlson, MD

Alise Carlson, MD, a resident at Cleveland Clinic, provided insight on how raising awareness for genetic leukodystrophies may ultimately improve misdiagnosis rates.

PF-06939926 Continues to Show Safety and Efficacy in Duchenne Muscular Dystrophy

An update on the phase 1b study of Pfizer’s investigational DMD treatment was presented at the MDA 2021 conference.

Variety of Stroke Data Presented at ISC 2021: Ralph Sacco, MD, MS, FAAN, FAHA

The chair of neurology and Olemberg Family Chair of Neurological Disorders at the University of Miami Miller School of Medicine detailed a number of presentations from ISC 2021.

IV Edaravone Reduces Chance of Death, Tracheostomy, PAV, and Hospitalization in ALS

Researchers conducted a post-hoc analysis of Study 19 to determine hazard ratios of milestone occurrences in amyotrophic lateral sclerosis.

7-Tesla MRI Use in Research: Jemima Akinsanya, DO, and Daniel Reich, MD, PhD

The duo from the National Institutes of Health discussed the advantages of the ultra-high resolution imaging technology in research.

SGT-001 Shows Improvements in Key DMD Measures, Microdystrophin Expression

Preliminary results from the IGNITE-DMD trial also showed a decreased in creatine kinase levels and improvements on NSAA and PODCI.

Expanding Research on MS Diagnosis Disclosure and Long-Term Impacts: Anne Kever, PhD

The postdoctoral researcher at Columbia University discussed the long-term plans to gain a better understanding of MS diagnosis disclosure and how it can impact other qualities of life.

NeuroVoices: Ralph Sacco, MD, MS, on Florida Stroke Registry, Advancing Stroke Knowledge

The chair of neurology and Olemberg Family Chair of Neurological Disorders at the University of Miami Miller School of Medicine discussed the abundance of research from the Florida Stroke Registry presented at ISC 2021.

CNS Demyelination and Autoimmune Neurology: Spencer Hutto, MD

The fellow of autoimmune neurology at Massachusetts General Hospital also discussed concerns of associations between multiple sclerosis and COVID-19.