Danielle Andrade, MD, MSc: Education for Adult Neurologists on Pediatric-Onset Epilepsies
September 19th 2019The professor of medicine, neurology, at the University of Toronto discussed the best ways for adult neurologists to ensure a smooth transition of care for patients with epilepsy entering their care.
Understanding Cerebral Venous Thrombosis: Rare But Sometimes Fatal
September 19th 2019The prognosis of cerebral venous thrombosis (CVT) is favorable compared with other types of stroke: almost 80% of patients with CVT recover without functional disability. Nevertheless, 5% to 10% of patients die in the acute phase.
NIH Cognitive Battery Effectively Screens for Cognitive Issues in Duchenne Muscular Dystrophy
September 19th 2019A prospective, cross-sectional assessment suggests that patients with DMD can be adequately assessed for cognition in a brief period of time using the NIHTB‐CB, and additionally suggested a cognitive vulnerability in mothers who were carriers of DMD mutation.
Jan Hillert, MD, PhD: The Blood-Brain Barrier in Multiple Sclerosis
September 19th 2019The professor and senior physician in the department of clinical neuroscience at the Karolinska Institutet discussed the evolving understanding of the blood-brain barrier in MS, and what might still be left to uncover.
Nusinersen's Long-Term Success in SMA Lends Support to Higher Dose Trial
September 19th 2019Further analysis of the SHINE trial suggest nusinersen is linked to 6-year maintained improvement in patients with SMA. Biogen has announced a new global trial of a 50 mg loading dose in a broader cohort.
Mobile Stroke Unit Triages Patients With Higher Accuracy Than Optimized Management
September 18th 2019In a time where more than half of all patients with acute stroke and most patients with severe stroke arrive at the hospital via emergency medical services, a study suggests mobile stroke units are better equipped to accurately triage patients.
Achthar Gel Associated With Lower Cost Per Response in Multiple Sclerosis Relapse
September 18th 2019Mallinckrodt’s repository corticotropin injection was shown to have a lower cost per patient response compared to other late-line treatments for multiple sclerosis relapses, costing an estimated $148,528 less per response.
Danielle Andrade, MD, MSc: Ensuring Smooth Transitions to Adult Epilepsy Care
September 18th 2019The professor of medicine, neurology, at the University of Toronto discussed the best ways for pediatric neurologists to ensure a smooth transition of care for patients with epilepsy who are leaving the pediatric system.
R. Edward Hogan, MD: Clinician Takeaways for Using Diazepam Nasal Spray
September 17th 2019The director of the adult epilepsy center at Washington University in St. Louis discussed the takeaways for clinicians regarding the use of intranasal diazepam as a treatment for runs of seizures in patients with refractory epilepsy.
Jan Hillert, MD, PhD: Treating the Non-Inflammatory Aspects of MS
September 16th 2019The professor and senior physician in the department of clinical neuroscience at the Karolinska Institutet spoke to the aspects of MS—such as brain volume loss—which are not currently being addressed by the available disease-modifying therapies.
Relapsing MS Treatment With Natalizumab Linked to High NEDA Rate Over 4 Years
September 16th 2019According to new data from STRIVE, 75.4% of those treated with natalizumab achieved overall No Evidence of Disease Activity status by year 4, and no patients had incidence of progressive multifocal leukoencephalopathy.
Elenbecestat Trials in Early Alzheimer Disease Terminated for Poor Risk-Benefit Profile
September 13th 2019The phase 3 clinical trial program included 2 identical, multicenter, double-blind, and placebo-controlled trials of the BACE inhibitor intended for the treatment of early Alzheimer disease.
Ocrelizumab Is Beneficial Across Long-Term Multiple Sclerosis Outcomes
September 13th 2019The global head of neuroimmunology at Genentech spoke about the wealth of data being presented on its anti-CD20 monoclonal antibody ocrelizumab, as well as the success thus far in trials of its NMOSD agent, satralizumab.
Alberto Ascherio, MD, DrPH: Using Vitamin D to Treat MS
September 12th 2019The professor of epidemiology and nutrition at Harvard TH Chan School of Public Health discussed what might be an optimal dose of vitamin D supplementation in MS, and how vitamin D deficiency should be addressed as a modifiable risk factor.
Ponesimod Superior to Teriflunomide in Lowering MS Relapse Rates
September 12th 2019New phase 3 data from the OPTIMUM head-to-head trial show that 20-mg ponesimod resulted in a significantly lower annualized relapse rate in adults with multiple sclerosis compared to 14-mg teriflunomide at 108 weeks.