Headache and Migraine

Surgery may offer relief from debilitating migraines. View the results of 3 different procedures.

PACAP38 is a potent aggravator of migraine, a new study shows. This provides several new potential therapeutic targets -- most prominently a specific PACAP receptor PAC1.

Intriguing research is helping to shape our understanding of the functional connectivity and brain structure of migraineurs.

Highlights of the first large study to describe the characteristics of post-traumatic headache and treatment response in children are summarized here.

A novel drug-device may not only be a promising non-oral triptan acute migraine treatment, but may be more efficacious than its oral counterpart.

Advances in neurology science and patient care continue to make news even before the doors to the AAN 2015 Annual Meeting officially open on Saturday. These are the top stories.

The SPG is a promising target for migraine treatment, but robust evidence of efficacy for routine use of noninvasive device–mediated SPG blockade is needed.

Do you have a patient with "radiologically isolated syndrome" -- and, if so, what do you tell your patient?

Efficacy of acute medication matters beyond just treating a single migraine. It may increase the risk of worsened disease.

The ultimate cause is found in only about half of patients, so improved understanding of the prognostic and diagnostic features is of high priority.

Despite butterbur’s potential efficacy, doubts are increasing about its long-term safety given of the risk of liver damage and the lack of an actively regulated preparation.

This report reflects the changing nature of guidelines toward evidence-based treatment rather than expert opinion. A companion piece will help translate evidence-based guidelines to clinical practice.

This is a newly identified association between the conditions, and they may share a common underlying link.

Many patients with brain tumors present with isolated headaches but no other symptoms. Use neuroimaging to help the diagnosis, or cut costs?

Transcranial magnetic stimulation is a promising, effective, well-tolerated and safe treatment option for migraine with and without aura, episodic or chronic.

These review articles published in 2014 cover a variety of headache issues, and all are free courtesy of PubMed. Take a look.

Get to the root of the latest research findings on nervous system disorders and test your brainpower with this quick 5-question quiz.

Pain relief is better with a triple combination medication that includes acetaminophen than with acetaminophen by itself, researchers found, suggesting a new therapeutic option.

Some very recent research findings have added to the literature on the associations between migraine and depression, anxiety, and other disorders. Highlights here.

Knowing the direction of the headache's origin, while clinically difficult to ascertain on a consistent basis, has shown some predictive value for migraines.

In this podcast, Ann Scher, PhD, lead author in a recently published study, gives a succinct overview of the details and briefly discusses what the findings may suggest.

A sudden severe headache with emesis brings a 35-year-old man to the ED. Research on his smart phone has satisfied him that this is a post-coital event and therefore, harmless. He refuses a lumbar puncture.

Chiari 1 malformation was found to be the cause of this man's year's long history of headache and severe neck pain. Here: a quick quiz on this anomaly.

Here: highlights from a systematic review that these authors view as a substantial step forward in establishing an evidence-based approach to migraine treatment in the acute care setting.

So many good headache studies . . . so little time! Here's a little help.

This FDA-approved treatment for migraine is a welcome alternative for patients who have significant medication intolerances or who wish to try a non-pharmacologic approach to treatment.

The frequency of migraine attacks is higher in women during perimenopause and postmenopause than in premenopause, a new study shows.