Sleep Disorders

The FDA has granted a Breakthrough Therapy and Fast Track Designation to pitolisant for cataplexy in patients with narcolepsy, as Harmony Biosciences prepares a new drug application for the drug.

The FDA has accepted an application for solriamfetol as a treatment for excessive sleepiness associated with narcolepsy or obstructive sleep apnea, with a PDUFA action date set for December 20, 2018.

The perception of good vibes and bad vibes is among the most difficult human experiences to define. The feeling that something “feels right” or that something “just isn’t right” has been attributed to multiple factors.

The encephalitis lethargica epidemic of 1916-1930 is estimated to have affected at least half a million of people in Europe and still remains a mystery.

What's the science behind predictive dreams?

The synthetic cannabis-like therapy dronabinol was effectively used to treated patients with obstructive sleep apnea, offering a potentially better alternative to CPAP machines.

Do you consider sleep deprivation to be a possible contributor to your patients’ symptoms? Do you routinely ask your patients about sleep deprivation?

A number of agents are being investigated as potential new therapies for narcolepsy. Here's a brief overview.

Orexin B protects vulnerable midbrain neurons from degeneration and preserves their function. This sleep-promoting protein could provide a new target for potential treatments.

Contrary to prevailing thought, alcohol promotes sleep by affecting homeostasis rather than circadian rhythms. So should drinking be used as a sleep aid?

Increased orexin in this disorder is associated with disease severity, total tau protein levels, sleep impairment, and cognitive deterioration.

A significant percentage of patients with MS in the sample screened positive for 1 or more sleep disorders. Most were undiagnosed.

Recent studies have suggested that H1N1 influenza might be the trigger for some patients, but a number of interesting questions remain.