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Articles

The committee all agreed that tofersen presents a favorable risk-benefit profile in this particularly challenging patient population. 

FDA AdComm on Tofersen Supports NfL as Surrogate End Point of Clinical Benefit, But Is It Enough for Approval?

After results indicated significant slowing of ALS disease progression, Coya noted it plans to file an IND with the FDA in the second half of 2023 for a potential clinical study thereafter.

Treg Suppressing Agent COYA 302 Shows Slowing of ALS Disease Progression

If approved, ABBV-951 will become the first subcutaneous delivery of carbidopa/levodopa, often considered the standard of care for symptom management for patients with Parkinson disease.

FDA Issues Complete Response Letter for AbbVie’s 24-Hour Continuous Carbidopa/Levodopa Pump

The professor of neurology and pediatrics at University of Rochester Medical Center shared her thoughts on the 2023 MDA Clinical and Scientific Conference, and the progress made in the treatment of neuromuscular disorders. 

NeuroVoices: Emma Ciafaloni, MD, on Mounting Progress in the Neuromuscular Field, Duchenne Muscular Dystrophy

The neurologist and migraine expert from NYU Langone Health.

Videos

The neurologist and migraine expert from NYU Langone Health shared her reactions to the recently approved zavegepant nasal spray (Zavzpret; Pfizer) for the treatment of migraine. [WATCH TIME: 5 minutes]  

Newly Approved Migraine Nasal Spray Offers Alternative Treatment to Injections, Oral Medications: Shae Datta, MD

Slideshows

Here's the latest multidisciplinary MS research published online first in the International Journal of MS Care.

IJMSC Online First: March 2023

Director, Comprehensive Epilepsy Center, NYU Langone Health

The director of the Comprehensive Epilepsy Center at NYU Langone discussed the importance of healthy eating habits and whether all individuals with epilepsy should consider dieting early in their life. [WATCH TIME: 4 minutes]

Importance of Establishing Healthy Eating Habits in Epilepsy: Orrin Devinsky, MD

The vascular neurologist at Cleveland Clinic provided an overview of a study that assessed the extent HbA1c impacts the relationship between mechanical thrombectomy and poor outcomes. [WATCH TIME: 3 minutes]

Effect of HbA1c Elevation, Glycemic Control Following Mechanical Thrombectomy: David Baker, DO

The stroke condition center is a comprehensive resource for clinical news on the diagnosis, treatment, and management of stroke. Read more at NeurologyLive.



Stroke | Clinical Neurology News & Insights | NeurologyLive

NeurologyLive is your direct connection to the latest neurology news and interviews with expert neurologists in multimedia formats.

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Clinical

 stroke clinical focus page serves as a resource for updates and information related to the clinical care and management of stroke and cerebrovascular disease, featuring news, podcasts, and videos about the latest FDA actions, clinical guideline updates, interviews with physicians, and study and clinical trial findings. The page includes information on stroke, large vessel occlusion, subcranial hemorrhage, intracranial hemorrhage, ischemic stroke, and more.

's featured content in the carousel below.

Here, view results of CT of the head and axial FLAIR and axial diffusion-weighted MRI studies. What is in your differential? What is your diagnosis?  

Loss of Consciousness in an Elderly Woman With Prior CVA: What Cause?

The Alzheimer drug may help repair some damage caused by stroke. In a rodent model, treated animals showed improved motor behavior and restored sensory mapping in the cortex. Here, more about the proposed mechanism. 

Memantine and Recovery After Stroke

 to subscribe on your favorite streaming service.

 podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis, Parkinson disease, dementia, sleep disorders, and more.

Episode 82, "Managing Seizures After Ischemic Stroke," features an exclusive interview with Carolina Ferreira Atuesta, MD, MSc, a scientific researcher and clinical data manager at the Icahn School of Medicine at Mount Sinai. She spoke about research she and colleagues recently presented at the 

 on poststroke epilepsy, the ongoing clinical efforts to manage seizures occurring after stroke, what studies still need to explore, and more.

, a streaming channel from MJH Life Sciences

. Check out new content and shows every day, only at

The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

FDA Accepts New Drug Application for Duchenne Therapy Vamorolone

Enrollment for Pivotal Phase 3 PHOENIX Study of AMX0035 Completed

Alzheimer’s Association Panel Offers Considerations for New Definition of Meaningful Change in Drug Trials

Sanofi Discontinues Phase 3 Study of Tolebrutinib in Myasthenia Gravis

 – Goals of the study and main findings

 – The understanding of this association in clinical care

 – Current state of prognostication post stroke

 – The lack of standardized approach to monitoring

 podcast. Be sure to leave a rating and review for the show. Thanks for listening!

Hoping to listen on your favorite podcast app? See below:

REFERENCES
1. Atuesta FC. Seizures After Ischemic Stroke: A Matched Multicenter Study. Presented at: AES Annual Meeting; December 2-6, 2022; Nashville, TN, and virtual. SIG.
2. Ferreira-Atuesta C, Döhler N, Erdélyi-Canavese B, et al. Seizures after Ischemic Stroke: A Matched Multicenter Study. 

. 2021;90(5):808-820. doi:10.1002/ana.26212

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Carolina Ferreira Atuesta, MD, MSc. [LISTEN TIME: 26 minutes]

Episode 82: Managing Seizures After Ischemic Stroke

Episode 75, "Focusing on the Future of Neurology," features a trio of exclusive interviews with the chairs of the recently hosted International Congress on the Future of Neurology (IFN), including Stephen Krieger, MD, professor of neurology and neurologist at the Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai; Richard Isaacson, MD, director of the Center for Brain Health at the Florida Atlantic University Schmidt College of Medicine; and Jessica Ailani, MD, associate professor of neurology and director of the MedStar Georgetown Headache Center. They joined the show to recap their experience at the 2022 IFN meeting, discuss the value of cross-specialty interactions, share their perspective on the future of their fields, and more.

. Check out new episodes of a variety of shows, airing every single day, only on

The 4th Annual International Congress on the Future of Neurology

 showcased the most recent advancements in neurologic disorders, featuring practice-changing discussions and presentations of strategies for incorporating new therapies into practice, as well as a comprehensive overview of pharmacological and nonpharmacological modalities.

Occurring over 2 days, the educational program delivered information through a mix of clinical data presentations, case-based discussions, and robust Q&A sessions. Each year, this symposium brings together world-renowned experts in their respective fields to discuss the impact of new evidence and novel agents in the treatment of neurologic disorders in a highly practical and engaging format.

To learn more about the IFN Congress and other Physician's Education Resource CME activities, visit

Episode Breakdown

Mind Moments®, a podcast from NeurologyLive®, brings you exclusive interviews with Stephen Krieger, MD; Richard Isaacson, MD; and Jessica Ailani, MD. [LISTEN TIME: 24 minutes]

Episode 75: Focusing on the Future of Neurology

Episode 73, "Updates in Epilepsy Treatment," features an exclusive interview with Ambereen Mehta, MD, MPH, palliative care physician and assistant professor of medicine, Johns Hopkins Bayview Medical Center. She joined the show to discuss palliative care and its evolving role in the care paradigm for patients with chronic neurologic disease, as well as its history in the United States, how it differs from hospice care, and more.

To learn more about neuropalliative care, head to our 

International Neuropalliative Care Society (INPCS) partner page

FDA Accepts Application for Trofinetide in Rett Syndrome

LIFT-AD Study Amended to Assess Alzheimer Disease Agent Fosgonimeton as Monotherapy

Tolerizing MS Vaccine Displays Efficacy in Model of Relapsing-Remitting Multiple Sclerosis

REFERENCES
1. Shemme AJ, Phillips JN, Bloise R, Koehler TJ, Gorelick PB, Francis BA. The Impact of a Neurocritical Care and Neuropalliative Collaboration on Intensive Care Unit Outcomes. 

. 2022;39(6):687-694. doi:10.1177/10499091211060055
2. Mehta AK, Wright SM, Wu DS, Harris CM. Palliative Care Involvement in Patients Hospitalized in the United States with Aneurysmal Subarachnoid Hemorrhage. 

. 2021;24(10):1555-1560. doi:10.1089/jpm.2021.0116
3. Williamson TL, Adil SM, Shalita C, et al. Palliative Care Consultations in Patients with Severe Traumatic Brain Injury: Who Receives Palliative Care Consultations and What Does that Mean for Utilization? 

. 2022;36(3):781-790. doi:10.1007/s12028-021-01366-2
4. Bužgová R, Kozáková R, Bar M. The effect of neuropalliative care on quality of life and satisfaction with quality of care in patients with progressive neurological disease and their family caregivers: an interventional control study. 

. 2020;19(1):143. doi:10.1186/s12904-020-00651-9
5. Mehta AK, Jackson NJ, Wiedau-Pazos M. Palliative Care Consults in an Inpatient Setting for Patients With Amyotrophic Lateral Sclerosis. 

. 2021;38(9):1091-1098. doi:10.1177/1049909120969959
6. Lou W, Granstein JH, Wabl R, Singh A, Wahlster S, Creutzfeldt CJ. Taking a Chance to Recover: Families Look Back on the Decision to Pursue Tracheostomy After Severe Acute Brain Injury. 

. 2022;36(2):504-510. doi:10.1007/s12028-021-01335-9.
7. Miyasaki JM, Kluger BM (ed). 

. Neuropalliative Care - Part I. 2022;190:2-243
8. Lou W, Granstein JH, Wabl R, Singh A, Wahlster S, Creutzfeldt CJ. Taking a Chance to Recover: Families Look Back on the Decision to Pursue Tracheostomy After Severe Acute Brain Injury. 

. 2022;36(2):504-510. doi:10.1007/s12028-021-01335-9
9. Phillips JN, Besbris J, Foster LA, Kramer NM, Maiser S, Mehta AK. Models of outpatient neuropalliative care for patients with amyotrophic lateral sclerosis. 

. 2020;95(17):782-788. doi:10.1212/WNL.0000000000010831

International Neuropalliative Care Society (INPCS)

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Ambereen Mehta, MD, MPH. [LISTEN TIME: 40 minutes]

Episode 73: The Role of Palliative Care in Neurology

Episode 61, "2022 AAN Annual Meeting Highlights," features interviews with a number of individuals who presented data and spoke at the American Academy of Neurology Annual Meeting, on topics ranging from COVID-19's clinical presentation, overall trends in the care of patients with multiple sclerosis, the potential of regenerative medicine in traumatic brain injury, the real-world and long-term use of new therapy for Lennox-Gastaut syndrome, the optimal timing for the newest therapy in neuromyelitis optica spectrum disorder, the Axon Registry and incorporating EHR information into its data collection, and the impact of the pandemic on clinician burnout and mental health. Those featured include Jennifer Frontera, MD; Stephen Krieger, MD; Peter McAllister, MD; Kelly Knupp, MD, MSCS; Bruce Cree, MD, PhD, MAS; Shrujal Baxi, MD, MPH; and Indu Subramanian, MD.

Note: As part of AAN policy for the Annual Meeting, all individuals were asked to remain masked throughout the week, so there may be some moments of muffled noises as participants adjust or shift their masks.

Click here for more coverage of AAN 2022.

American Academy of Neurology Annual Meeting

Mind Moments®, a podcast from NeurologyLive®, brings you exclusive interviews with Jennifer Frontera, MD; Stephen Krieger, MD; Peter McAllister, MD; Kelly Knupp, MD, MSCS; Bruce Cree, MD, PhD, MAS; Shrujal Baxi, MD, MPH; and Indu Subramanian, MD. [LISTEN TIME: 32 minutes]

Episode 61: 2022 AAN Annual Meeting Highlights

 podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis (MS), Parkinson disease, dementia, sleep disorders, and more.

Episode 54, "The Shortage of Neurologists," features an exclusive interview with Jennifer Majersik, MD, MS, chief, division of vascular neurology, and professor of neurology, University of Utah, who along with 9 other colleagues, authored a report from the American Academy of Neurology (AAN) 2019 Transforming Leaders Program on the ongoing shortage of physicians in neurology. She offered her perspective on the challenge and how it can be addressed from an individual and institutional level.

REFERENCES
Majersik JJ, Ahmed A, Chen IA, et al. A shortage of neurologists – we must act now: A report from the AAN 2019 transforming leaders program. 

. Published online April 30, 2021. doi:10.1212/WNL.0000000000012111

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Jennifer Majersik, MD, MS.

Episode 54: The Shortage of Neurologists

The Mind Moments podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis (MS), Parkinson disease, dementia, sleep disorders, and more.

Episode 48, "RapidAI's Effect on Stroke Imaging," features an exclusive interview with Gregory W. Albers, MD, director, Stanford Stroke Center, and Coyote Foundation Professor of Neurology and Neurological Sciences, Stanford Medical Center, and founder, RapidAI. He shared his insight into the development and clinical use of RapidAI, a platform that leverages artificial intelligence to create enhanced, high-quality images from noncontrast CT, CT angiography, CT perfusion, and MRI diffusion and perfusion data, aiming to expedient diagnoses, treatment, and transfer decisions.

Lecanemab Rolling Submission for Alzheimer Disease Initiated by Eisai, Biogen

Fenfluramine sNDA Submitted for Lennox-Gastaut Syndrome

Atogepant Approved for Episodic Migraine Prevention

 to subscribe to the Mind Moments podcast. Be sure to leave a rating and review for the show. Thanks for listening!

"Mind Moments," a podcast from NeurologyLive, brings you an exclusive interview with Gregory W. Albers, MD.

Episode 48: RapidAI's Effect on Stroke Imaging

The Mind Moments podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis, Parkinson disease, dementia, sleep disorders, and more.

Episode 44, "AHA/ASA Updates to the Stroke Care Model" features an exclusive interview with Mitchell S.V. Elkind, MD, MS, MPhil, president, American Heart Association/American Stroke Association (AHA/ASA), and chief, division of neurology clinical outcomes research and population sciences, Columbia University. He discussed the AHA/ASA's recent scientific statement outlining the role of primary care physicians in the poststroke phase of care, as well as the recently updated secondary stroke prevention guidelines.

The stories feature in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

Expanded Data From FIREFISH Published, Risdiplam Continues to Improve SMA Outcomes

FDA Accepts Resubmission of Diazepam Buccal Film NDA for Seizure Clusters

Dosing of WVE-004 Treatment Begins In Frontotemporal Dementia and ALS

REFERENCES
1. Kernan WN, Viera AJ, Billinger SA, et al. Primary Care of Adult Patients After Stroke: A Scientific Statement From the American Heart Association/American Stroke Association.

. Published online July 15, 2021. doi: 10.1161/STR.0000000000000382.
2. Kleindorfer DA, Towfighi A, Chaturvedi S, et al. 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: A guideline from the American Heart Association/American Stroke Association.

. Published online May 24, 2021 doi: 0.1161/STR.0000000000000375

"Mind Moments," a podcast from NeurologyLive, brings you an exclusive interview with Mitchell S.V. Elkind, MD, MS, MPhil.

Episode 44: AHA/ASA Updates to the Stroke Care Model

Episode 35, "Highlights From the AAN Annual Meeting," features interviews with Stephanie J. Nahas, MD; Bruce Cree, MD, PhD, MAS; Sana Somani, MD, MBBS; Hubert Fernandez, MD; Daniel Ontaneda, MD, PhD; and Richard Gershon, PhD. Each of them discussed data that they respectively presented at the American Academy of Neurology Annual Meeting. These presentations included novel tools for tracking cognitive decline, analyses of subpopulations of patients with migraine treated with new medicines, the disparities faced by women and Black individuals going through stroke rehabilitation, and more.

REFERENCES
1. Nahas S, Ning X, Cohen JM, Barash S, Campos VR, Silberstein SD. Efficacy of fremanezumab in patients with moderate and higher frequency episodic migraine. Presented at 2021 American Academy of Neurology Annual Meeting. Abstract P10.046
2. Nahas S, Jurgens TP, Kessler Y, et al. Cardiovascular safety of fremanezumab in patients with migraine and cardiovascular medical history or risk factors: A pooled analysis of phase 3 studies. Presented at 2021 American Academy of Neurology Annual Meeting. Abstract P10.034
3. Cree B, Bennett J, Weinshenker B, et al. Long-term efficacy outcomes with inebilizumab treatment in NMOSD: the N-MOmentum trial. Presented at 2021 American Academy of Neurology Annual Meeting; April 17-22. Abstract P15.076
4. Cree B, Bennett J, Weinshenker B, et al. Long-term safety outcomes with inebilizumab treatment in NMOSD: the N-MOmentum trial. Presented at 2021 American Academy of Neurology Annual Meeting; April 17-22. Abstract P15.100
5. Somani S, Nanavati H, Xiaohua Z, Lin C. African American women have lower functional performance during acute inpatient rehabilitation after intracerebral hemorrhagic strokes. Presented at 2021 American Academy of Neurology Annual Meeting; April 17-22. Abstract P5 073
6. Fernandez H, Odin P, Standaert D, et al. Identifying gaps in Parkinson disease patients eligible for device-aided therapies: results from using the MANAGE-PD tool in patients from G7 countries. Abstract P14.117
7. Ontaneda D, Qu J, McGinley M, et al. A Data Driven Approach to Define Disease Course Categories in MS. Presented at 2021 American Academy of Neurology Annual Meeting; April 17-22. Abstract P15.244
8. Pila S, Novak M, Weintraub S, et al. The Mobile Toolbox (MBT): A Completely Remote Platform for Cognitive Research. Presented at 2021 American Academy of Neurology Annual Meeting; April 17-22. Abstract P7.086

"Mind Moments," a podcast from NeurologyLive, brings you exclusive interviews with Stephanie J. Nahas, MD; Bruce Cree, MD, PhD, MAS; Sana Somani, MD, MBBS; Hubert Fernandez, MD; Daniel Ontaneda, MD, PhD; and Richard Gershon, PhD.

Episode 35: Highlights From the AAN Annual Meeting

Episode 25, "2020 Wrap-Up: Silver Linings," features an interview with Jennifer Frontera, MD, neuro-intensivist, NYU Langone Health, who we spoke with during the early days of the pandemic. This time, she discussed the complications in determining the cause of death with COVID-19, the need for continued social distancing and mask-wearing, the impact the pandemic has had on her mental health, and her silver linings in spite of these challenges.

Editor's note: This interview was taped pre-vaccine approval in the United States. For updates on the vaccine news, head to 

In that same light, we reached out to a number of physicians across neurology specialties to find out what their silver linings have been for their clinical practice despite the immense adversity that this year has brought. They are, in order of appearance:

"Mind Moments," a podcast from NeurologyLive, brings you an exclusive interview with Jennifer Frontera, MD, and a number of others.

Episode 25: 2020 Wrap Up: Silver Linings

The Mind Moments podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis, Parkinson disease, dementia, sleep disorders, and more. 

Episode 11, "Exploring the Link Between Stroke and COVID-19" features an interview with Shadi Yaghi, MD, associate professor of neurology at NYU Grossman School of Medicine; director of Clinical Vascular Neurology Research at NYU Langone Health; and director of Vascular Neurology at NYU Langone Hospital-Brooklyn. Yaghi offers his perspective on a recent study he and colleagues conducted of patients with stroke and COVID-19 and the difficulties in understanding their relationship.

 to subscribe to the Mind Moments podcast. Thanks for listening!

Yaghi, S, Koto I, Torres J, et al. SARS2-CoV-2 and Stroke in a New York Healthcare System. Stroke. 2020;51:00—00. doi: 10.1161/STROKEAHA.120.030335

Montefiore Health System

"Mind Moments," a podcast from NeurologyLive, brings you an exclusive interview with Shadi Yaghi, MD.

Episode 11: Exploring the Link Between Stroke and COVID-19

Here's some of what is coming soon to NeurologyLive® this week.

This Week on NeurologyLive® — March 20, 2023

Take 5 minutes to catch up on NeurologyLive®'s highlights from the week ending March 17, 2023.

NeurologyLive® Friday 5 — March 17, 2023

Among countries with non-zero mechanical thrombectomy access, there was a 460-fold difference in availability of this care between the country with the highest and lowest access rate reported.

Global Access to Mechanical Thrombectomy Significantly Low, Study Suggests

This Week on NeurologyLive® — March 13, 2023

Take 5 minutes to catch up on NeurologyLive®'s highlights from the week ending March 10, 2023.

NeurologyLive® Friday 5 — March 10, 2023

"One of the interesting findings is that we didn’t see a clear influence on hemorrhagic transformation in those with HbA1c greater than 6.5; however, when we stratified it and looked at that very poor glycemic control, that’s where we saw the impact on hemorrhagic transformation."

Blood glucose is often elevated in acute stroke, and higher admission glucose levels are associated with larger lesions, greater mortality and poorer functional outcome. Previous studies have shown that hyperglycemia is an independent predictor of hemorrhagic transformation and poor clinical outcome in patients undergoing mechanical thrombectomy (MT); however, it is less clear to what extent HbA1c impacts these relationships. At the 2023 International Stroke Conference (ISC), a group of investigators from Cleveland Clinic assessed the association between severity of poor glycemic control, functional independence, and hemorrhagic transformation.

Conducted between January 2016 and January 2022, the analysis included 657 patients who underwent MT for large vessel occlusion. Among these, the observed HbA1c value was less than 6.5 mg/dl (n = 535), 6.5-8.0 mg/dl (n = 72), or greater than 8.0 mg/dl (n = 50), with good glycemic control described as HbA1c less than 6.4 mg/dl. Above all, suboptimal glucose control and diabetes was associated with worse outcomes, its effect on hemorrhagic transformation risk was only seen in those with poor glycemic (HbA1c > 8.0) in the single center analysis.

Stroke

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