Mitzi Joi Williams, MD

In this episode titled "Long-Term Management of MS: Monitoring Progression and Supporting Patient Wellness While on Anti-CD20 DMTs," Dr. Williams asks the panel what the clinical conversation looks like for patients who have been on therapy for five to seven or more years — and what new priorities have emerged.

Shared decision-making has become a foundational element of contemporary multiple sclerosis (MS) care, particularly as the number of available disease-modifying therapies has expanded.

This episode discusses "The MS 'Wearing-Off' Phenomenon: Separating Symptom Burden from Immunological Change." Dr. Williams introduces the wearing-off phenomenon — a patient experience in which symptoms feel worse as the next anti-CD20 dose approaches. The panel explores whether this represents a true immunological change or a symptom-level phenomenon.

Ensuring safety over the course of high-efficacy therapy remains a central concern in the management of relapsing multiple sclerosis (MS).

In this episode titled "Extended Interval Dosing of Anti-CD20 Therapies: Benefits, Risks, and Real-World Experience," moderator Dr. Mitzi Joi Williams introduces the concept of extended interval dosing (EID): rather than dosing on a fixed six-month or monthly schedule, could practitioners dose less frequently while maintaining efficacy — whether for cost, safety, or patient preference?

Williams describes long-term treatment success with ofatumumab in relapsing MS, noting that ASCLEPIOS trial and extension data support sustained reductions in relapse rates, MRI lesions, and confirmed disability progression.

This episode discusses "Hypogammaglobulinemia in MS Patients on Anti-CD20 Therapy: When to Act." Dr. Williams identifies hypogammaglobulinemia — low IgG levels resulting from prolonged B-cell depletion — as one of the most clinically consequential long-term complications of anti-CD20 therapy, and asks the panel how they identify high-risk patients and manage this finding.

Williams explains that at-home, once-monthly ofatumumab is generally well received by patients with relapsing MS, offering convenience for those with active work and family lives while addressing concerns about injections and treatment scheduling.

Mitzi Joi Williams, MD, is joined by Dietrich Cox, MD, and Sheree Love to discuss the causes, evaluation, and management of spasticity in neurologic conditions.

In this episode titled "Managing Infection Risk and Safety Monitoring with Anti-CD20 MS Disease Modifying Therapy," Dr. Williams raises the issue of infection risk — a topic of increasing clinical relevance.

With the first anti-CD20 therapy approved for MS now more than ten years in clinical use, in this episode titled "Long-Term Efficacy of Anti-CD20 Therapies in MS: What the Evidence Shows," Dr. Williams asks Dr. Krieger what the long-term evidence reveals about efficacy — and whether there have been any surprises.

Williams outlines how active disease features, lifestyle needs, and prior experience with injectable therapies inform selection of ofatumumab as a high-efficacy, self-administered option for patients with relapsing multiple sclerosis.

Williams describes how the shift toward early use of high-efficacy therapy in relapsing MS has brought ofatumumab, an at-home, subcutaneous anti-CD20 agent, into treatment discussions at the start of the disease course.

In this episode, moderator Dr. Mitzi Joi Williams discusses Anti-CD20 Therapies in multiple sclerosis with Dr. Stephen Krieger, Dr. Benjamin Greenberg, and Dr. Riley Bove. Dr. Williams notes that while three anti-CD20 agents are FDA-approved for MS (ocrelizumab approved in 2017, followed by ofatumumab and ublituximab), rituximab has been used off-label for many years. Though these agents target the same molecule, they differ in meaningful ways.

In "Why Anti-CD20 Therapy Has Become a Cornerstone of MS Treatment" episode, panelists explore the anti-CD20 drug class itself — a group of B-cell depleting therapies that have become the most commonly initiated treatments for MS in the United States. Experts recount that the field initially viewed B-cell targeting as counterintuitive in what was long considered a T-cell-mediated disease. However, experience and trial data have demonstrated that depleting CD19/CD20-positive B cells produces profound downstream immunological effects that dramatically suppress MS disease activity.

Mitzi Joi Williams, MD, sits down with Sheree Love and Mana Opang Owusu to discuss how movement supports brain health, function, and quality of life for people living with neurologic conditions.

In this episode focused on first-line MS treatments, Dr. Williams poses the practical question: when a newly diagnosed, treatment-naive patient with relapsing-remitting MS sits across from you, what guides your treatment recommendation?

How MS therapy choices balance patient preference, payer coverage, dosing convenience, and family planning as high-efficacy options expand.

In this episode, panelists explore the question of "MS Treatment Strategy: High-Efficacy Therapy vs. Escalation Approach." Dr. Williams frames the central question: with earlier MS diagnoses now possible, how has treatment philosophy shifted? The traditional "start low, go slow" escalation model has given way to a high-efficacy-first approach for many clinicians.

Welcome back to another Neurology Live Peer Exchange series. In this episode titled "Evolving MS Diagnostic Criteria: 2024 McDonald Criteria and What's New," moderator Dr. Mitzi Joi Williams discusses multiple sclerosis with Dr. Stephen Krieger.

Mitzi Joi Williams, MD, sits down with sleep specialist Shantel Branson, MD, to discuss how sleep impacts brain health, memory, mood, and long-term neurologic well-being.

Mitzi Joi Williams, MD, is joined by movement disorder specialists Chantale Branson, MD, MSCR, FAAN, and Keisha Young, MD, PhD, to discuss the causes, evaluation, and management of tremor disorders.

In this episode, Mitzi Joi Williams, MD, and Jacqueline Rosenthal, MD, review the past year in multiple sclerosis, highlighting emerging therapies, biomarkers, and evolving approaches to personalized, comprehensive care.

Mitzi Joi Williams, MD, and Carol Coleman break down insurance basics, prior authorizations, and practical strategies to help patients navigate cost and access challenges at the start of the year.

The effect of gaslighting on patients can result in serious harms, and although it is potentially common in the MS care continuum, whether it is deliberate or an institutional problem, it must be called out by providers.

The founder and chief executive officer of Joi Life Wellness Group Multiple Sclerosis Center provided insight on the barriers with expanding precision medicine and the need for additional biomarkers of clinical progression. [WATCH TIME: 3 minutes]

The founder and CEO of Joi Wellness Group Multiple Sclerosis Center explained her reasoning as to why she hopes telemedicine is here to stay. [WATCH TIME: 4 minutes]

Discussing the willingness to share data during the pandemic, the founder and CEO of Joi Life Wellness Group Multiple Sclerosis Center spoke to the positive effect of collaboration in the MS field. [WATCH TIME: 2 minutes]

The founder and CEO of Joi Life Wellness Group Multiple Sclerosis Center commented on the effect of the pandemic on needs for underrepresented populations in the multiple sclerosis space, as well as the pros and cons of telehealth. [WATCH TIME: 3 minutes]

The field of MS is shifting focus to issues such as understanding and tracking disease progression, approaches to treatment initiation, and the roles of diet and exercise in pathogenesis and disease course.