Opinion|Videos|November 2, 2026
Post-Hoc: Time Since Diagnosis Subgroups
Author(s)Suraj Muley, MD, FAAN, FRCP, FACP
Dr. Muley explains the rationale for examining disease duration: concern that longer disease may reduce reversibility due to structural muscle membrane changes, plus European data suggesting early B cell depletion may alter long-term disease course.
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Dr. Muley explains the rationale for examining disease duration: concern that longer disease may reduce reversibility due to structural muscle membrane changes, plus European data suggesting early B cell depletion may alter long-term disease course. The analysis grouped patients into <1 year, 1-4 years, and >=4 years. MG-ADL improvements: 5.4, 4.3, and 3.7 points; QMG: 5.2, 6.4, and 4.0. No significant difference across groups, indicating inebilizumab is effective regardless of disease duration.
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