Opinion|Videos|November 2, 2026
Safety & Long-Term Monitoring [BACKUP]
Author(s)Suraj Muley, MD, FAAN, FRCP, FACP
Dr. Muley addresses long-term safety of sustained B cell depletion, drawing a parallel to decades of use in MS.
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[BACKUP SEGMENT] Dr. Muley addresses long-term safety of sustained B cell depletion, drawing a parallel to decades of use in MS. Key monitoring recommendations: annual immunoglobulin levels (flag hypogammaglobulinemia; more frequent if infections arise); hepatitis B panel prior to each administration; TB screening based on risk profile. IVIG replacement is available for patients with confirmed low IgG and increased infection burden.
Note: Filmed as a backup to extend runtime -- not part of the original discussion guide.
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