Cleveland Clinic is a nonprofit, multispecialty academic medical center integrating outpatient and hospital care with research and education for better patient outcomes and experience. More than 4,500 staff physicians and researchers provide services through 20 patient-centered institutes. Cleveland Clinic is a 6,500-bed healthcare system with a main campus in Cleveland, 22 hospitals and over 220 outpatient locations. The health system includes five hospitals in Southeast Florida with more than 1,000 beds, a medical center for brain health in Las Vegas, a sports and executive health center in Toronto, and a 364-bed hospital in Abu Dhabi. Cleveland Clinic London, a 184-bed hospital, opened in March 2022. Cleveland Clinic is currently ranked as one of the nation’s top hospitals by U.S. News & World Report.
Exercise, Virtual Reality, and Exposing Prodromal Symptoms of Parkinson Disease: Jay Alberts, PhD
August 22nd 2022The Edward F. and Barbara A. Bell Endowed Chair at the Cleveland Clinic detailed how a new virtual reality tool elucidates prodromal symptoms from patients with Parkinson disease. [WATCH TIME: 3 minutes]
The Realities of Gender-Targeted Therapeutics for Alzheimer Disease: Jessica Caldwell, PhD
August 21st 2022The director of the Women’s Alzheimer’s Movement Preventer Center at Cleveland Clinic provided perspective on the possibility of gender-specific therapies to overcome disparities in Alzheimer disease. [WATCH TIME: 3 minutes]
Lessons About Alzheimer Disease and Related Dementias From GFAP, sTREM2 Astrocytes: Lynn Bekris, PhD
August 18th 2022The molecular biologist at the Cleveland Clinic Lerner Research Institute discussed research on the use of GFAP and sTREM2 in discerning dementia with Lewy bodies from Alzheimer disease. [WATCH TIME: 4 minutes]
Using Virtual Reality to Identify Early Signs of Parkinson Disease: Jay Alberts, PhD
August 15th 2022The Edward F. and Barbara A. Bell Family Endowed Chair at the Cleveland Clinic provided an overview of the Cleveland Clinic Virtual Reality Shopping platform, a virtual reality tool for Parkinson disease. [WATCH TIME: 5 minutes]
Using Initial Cognitive Symptoms to Predict Trajectories of Neurodegenerative Pathologies
August 6th 2022Jagan A. Pillai, MD, PhD, neurologist, Cleveland Clinic Lou Ruvo Center for Brain Health, discussed a recent study which found faster clinical progression in those with nonamnestic initial cognitive symptoms.
Feasibility and Limitations of Exoskeletons for Multiple Sclerosis Rehab: Francois Bethoux, MD
July 18th 2022The chair of Cleveland Clinic’s Department of Physical Medicine provided background on the usage of exoskeletons in the clinical and at-home settings for rehabbing patients with multiple sclerosis. [WATCH TIME: 2 minutes]
Realistic Expectations and Limitations in MS Rehab With Exoskeletons: Francois Bethoux, MD
July 14th 2022The chair of Cleveland Clinic’s Department of Physical Medicine discussed the different ways a newly approved robotic exoskeleton can improve gait in patients with multiple sclerosis. [WATCH TIME: 4 minutes]
NeuroVoices: Francois Bethoux, MD, on Innovating MS Rehabilitation With the EksoNR Exoskeleton
July 6th 2022The chair of Cleveland Clinic’s Department of Physical Medicine discussed a new rehabilitative approach using a robotic exoskeleton to improve fatigue and gait in patients with multiple sclerosis.
Assessing Early Evidence, Long-Term Potential of EksoRN Robotic Exoskeleton: Francois Bethoux, MD
July 3rd 2022The chair of Cleveland Clinic’s Department of Physical Medicine detailed a pilot study on the rehabilitative impacts of the EksoRN robotic exoskeleton in patients with multiple sclerosis. [WATCH TIME: 5 minutes]
Moderate-to-Severe Post-COVID-19 Sleep Disturbances Common, Especially in Black Individuals
June 8th 2022Patients with moderate-severe compared with normal-to-mild sleep disturbances had worse GAD-2 questionnaire scores, PHQ-2 scores, and PROMIS fatigue scores with no difference in age, sex, or hospitalization due to COVID-19.
Plasma Neurofilament Level Correlated With Symbol Digit Modality Scores Following Ozanimod Treatment
June 1st 2022Both ozanimod doses were associated with greater median reductions in plasma neurofilament light and mean improvements in SDMT score change than interferon beta-1a at month 12 of treatment.
NeuroVoices: Elia Pestana-Knight, MD, on the Importance of Ganaxolone’s Approval in CDD
April 6th 2022The pediatric epileptologist at Cleveland Clinic’s Epilepsy Center discussed data presented at AAN 2022 on the use of ganaxolone in CDD, as well as how its recent approval sets the stage for the future.
Next Steps in Tackling CDKL5 Deficiency Disorder Following First Approval: Elia Pestana-Knight, MD
April 3rd 2022The pediatric epileptologist from Cleveland Clinic provided commentary on the changes needed to improve research and drug development in CDKL5 deficiency disorder, as well as the organizations committed to advancing the state of care. [WATCH TIME: 3 minutes]
Ganaxolone’s Approval Springboards Future CDD Drug Development: Elia Pestana-Knight, MD
April 2nd 2022The pediatric epileptologist at Cleveland Clinic discussed the impact of ganaxolone’s approval for CDKL5 deficiency disorder and how it may create an opportunity for future pipeline agents. [WATCH TIME: 3 minutes]
Assessing, Validating Clinically Relevant Biomarkers for Alzheimer Disease: Jefferson Kinney, PhD
March 15th 2022The founding chair of the department of brain health at the University of Nevada Las Vegas discussed the plethora of Alzheimer disease biomarkers and the need for consensus on the value of each. [WATCH TIME: 3 minutes]