Videos

4 experts are featured in this series

In this episode, "Navigating CIDP Guidelines, Misdiagnosis, and Disease Variants," the panelists in neurology and neuromuscular medicine explore the practical utility of the 2021 EAN/PNS CIDP guidelines and the considerable complexity introduced by disease variants. The discussion opens with a question about monophasic CIDP, with one expert noting that 20–30% of patients can achieve drug-free remission after initial treatment, suggesting a subset of patients experience a self-limiting course that nonetheless meets the diagnostic threshold of progression or relapse beyond two months.

4 experts are featured in this series

Welcome back to another NeurologyLive Peer Exchange series. The panel opens with a discussion of CIDP prevalence, noting that estimates vary depending on the diagnostic criteria used. A strict case definition from a New South Wales population study places prevalence at approximately 1 per 100,000, while a more clinically based study from Olmsted County suggests a higher figure of around 1 in 10,000. One expert contextualizes this further, estimating that roughly 40,000–50,000 patients in the U.S. are affected, and that CIDP accounts for approximately 20% of patients presenting to peripheral neuropathy centers with initially unrecognized neuropathy. The panel characterizes CIDP as rare but not ultra-rare.

Experts featured in this series.

In the final episode, 'Multidisciplinary Approaches to Long-Term Narcolepsy Care,' the panelists explore the multidisciplinary challenges inherent in managing narcolepsy over the long term, opening with a candid discussion of how fragmented healthcare systems and limited communication infrastructure make true care coordination difficult. In practice, the burden of bridging different care teams often falls on the patient, with the expert panel encouraging patients to keep all providers informed of treatment changes to avoid conflicting approaches.

Experts featured in this series.

This episode, titled 'Optimizing Narcolepsy Treatment Through Polypharmacy,' features panelists discussing the role of polypharmacy in narcolepsy treatment, challenging the notion that a single agent is sufficient for most patients. While research suggests roughly 60% of narcolepsy patients are on multiple medications, the expert panel notes that in their own clinical practices the rate is considerably higher, reflecting a more aggressive pursuit of optimal outcomes. The anticipated arrival of orexin receptor agonists is acknowledged as potentially transformative, though the expert panel stops short of assuming any single agent will address the full spectrum of narcolepsy symptoms.